Adrenal gland-released vasostatin-I is a myocardial depressant factor.

Autor: Schneider F; Service de Médecine Intensive-Réanimation, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, France.; Inserm UMR 1121, Faculté de Chirurgie Dentaire, Hôpital Civil, 1 Place de l'Hôpital, Strasbourg, France.; Fédération de Médecine Translationnelle de Strasbourg, Faculté de Médecine, Rue Kirchleger, 67000, Strasbourg, France., Castelain V; Service de Médecine Intensive-Réanimation, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, France., Herbrecht JE; Service de Médecine Intensive-Réanimation, Hôpital de Hautepierre, Hôpitaux Universitaires de Strasbourg, France., Hellé S; Inserm UMR 1121, Faculté de Chirurgie Dentaire, Hôpital Civil, 1 Place de l'Hôpital, Strasbourg, France.; Fédération de Médecine Translationnelle de Strasbourg, Faculté de Médecine, Rue Kirchleger, 67000, Strasbourg, France., Metz-Boutigue MH; Inserm UMR 1121, Faculté de Chirurgie Dentaire, Hôpital Civil, 1 Place de l'Hôpital, Strasbourg, France.; Fédération de Médecine Translationnelle de Strasbourg, Faculté de Médecine, Rue Kirchleger, 67000, Strasbourg, France.
Jazyk: angličtina
Zdroj: British journal of clinical pharmacology [Br J Clin Pharmacol] 2020 Apr; Vol. 86 (4), pp. 825-828. Date of Electronic Publication: 2020 Feb 03.
DOI: 10.1111/bcp.14173
Abstrakt: Pheochromocytoma crisis is an exceptional consequence of the release of storage vesicles of the adrenal medulla. It is complicated by fulminant adrenergic myocarditis. It offers a unique opportunity to detect inotropic negative factors from neuroendocrine origin. Our objectives were (a) to describe a pheochromocytoma crisis, (b) to investigate in vivo myocardial depressant activities for the N-terminal 1-76 Chromogranin A-derived peptide, vasostatin-I (VS-I). A patient with a pheochromocytoma crisis was treated, including extracorporeal membrane oxygenation, until mass resection. Plasma concentrations of VS-I were time-dependently assessed with a specific immunoassay; correlations with invasive cardiovascular parameters were investigated. Increased VS-I concentrations were observed over 7 days until tumour resection. VS-I concentrations correlated positively with Chromogranin A levels, negatively with cardiac output and left ventricular stroke work index, but not with heart rate. This case illustrates the pharmacokinetics of VS-I in a pheochromocytoma crisis. It highlights myocardial depressant activity for this peptide at high concentrations.
(© 2019 The British Pharmacological Society.)
Databáze: MEDLINE
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