GENETIC DIVERSITY of OVINE HERPESVIRUS 2 STRAINS OBTAINED FROM MALIGNANT CATARRHAL FEVER CASES in EASTERN TURKEY.

Autor: Turan T; Sivas Cumhuriyet University Faculty of Veterinary Medicine, Department of Veterinary Virology, 58140, Sivas, Turkey. Electronic address: tturan@cumhuriyet.edu.tr., Isidan H; Sivas Cumhuriyet University Faculty of Veterinary Medicine, Department of Veterinary Virology, 58140, Sivas, Turkey. Electronic address: hisidan@cumhuriyet.edu.tr., Atasoy MO; Sivas Cumhuriyet University Faculty of Veterinary Medicine, Department of Veterinary Virology, 58140, Sivas, Turkey. Electronic address: mozan@cumhuriyet.edu.tr., Sozdutmaz İ; Erciyes University Faculty of Veterinary Medicine, Department of Veterinary Virology, 38280, Kayseri, Turkey. Electronic address: isozdutmaz@erciyes.edu.tr., Bulut H; Namik Kemal University Faculty of Veterinary Medicine, Department of Veterinary Virology, 59030, Tekirdag, Turkey. Electronic address: hbulut@nku.edu.tr.
Jazyk: angličtina
Zdroj: Virus research [Virus Res] 2020 Jan 15; Vol. 276, pp. 197801. Date of Electronic Publication: 2019 Nov 10.
DOI: 10.1016/j.virusres.2019.197801
Abstrakt: Malignant Catarrhal Fever (MCF) is a generalized, definitive lethal disease affecting the epithelial and lymphoid tissues of the respiratory and digestive tract, mainly cattle and some wild ruminants such as deer, buffalo or antelope. The sheep-related form of MCF is known to be present in Turkey and is caused by ovine herpesvirus 2 (OvHV-2). The aim of this study was to reveal the genetic diversity of OvHV-2 strains obtained from MCF cases in Eastern Turkey where the livestock industry has an important impact on economic activities. For this purpose, RTA (Replication and transcription activator), FGARAT (formylglycineamide ribotide amidotransferase) and some of glycoprotein genes (Ov7, Ov8 ex2, ORF27 and Ov9.5) were investigated in blood samples from 24 cattles, clinically diagnosed with MCF. Genomic data of chosen samples were furthermore used to characterize and undergo combined phylogenetic analysis to determine possible alleles and subvariants. The results showed that high level of OvHV-2 diversity existed in selected genes and strains carrying allelic variants might circulate both in two geographically distinct regions and in a region itself. Moreover, three different OvHV-2 types and various subtypes were identified based on multi locus approach. This study provides important data to epidemiological research and thereby helps to determine the source of the virus and understand the spread of the disease.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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