Polyphenol Profile and Pharmaceutical Potential of Quercus spp. Bark Extracts.

Autor:	Elansary HO; Plant Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia.; Floriculture, Ornamental Horticulture, and Garden Design Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, Egypt.; Department of Geography, Environmental Management, and Energy Studies, University of Johannesburg, APK campus, 2006, South Africa., Szopa A; Department of Pharmaceutical Botany, Medical College, Jagiellonian University, ul. Medyczna 9, 30-688 Kraków, Poland., Kubica P; Department of Pharmaceutical Botany, Medical College, Jagiellonian University, ul. Medyczna 9, 30-688 Kraków, Poland., Ekiert H; Department of Pharmaceutical Botany, Medical College, Jagiellonian University, ul. Medyczna 9, 30-688 Kraków, Poland., Mattar MA; Department of Agricultural Engineering, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia., Al-Yafrasi MA; Plant Production Department, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia., El-Ansary DO; Precision Agriculture Laboratory, Department of Pomology, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, Egypt., El-Abedin TKZ; Department of Agricultural Engineering, College of Food and Agriculture Sciences, King Saud University, Riyadh, Saudi Arabia., Yessoufou K; Department of Geography, Environmental Management, and Energy Studies, University of Johannesburg, APK campus, 2006, South Africa.
Jazyk:	angličtina
Zdroj:	Plants (Basel, Switzerland) [Plants (Basel)] 2019 Nov 09; Vol. 8 (11). Date of Electronic Publication: 2019 Nov 09.
DOI:	10.3390/plants8110486
Abstrakt:	Targeted profiling of polyphenols in trees may reveal valuable sources of natural compounds with major applications in pharmacology and disease control. The current study targeted the profiling of polyphenols using HPLC-DAD in Quercus robur , Q. macrocarpa and Q. acutissima bark extracts. Free radical scavenging of each extract was investigated using antioxidant assays. Antimicrobial activities against a wide spectrum of bacteria and fungi were explored, as well as anticancer activities against different cancer cell lines. The HPLC-DAD analyses revealed the availability of several polyphenols in high amounts, including ellagic acid (in Q. robur ) and caffeic acid (in Q. macrocarpa ) in all three species. The bioactivity assay revealed high antioxidant activity in Q. robur compared to that of the other species, as well as phenolic standards. The three oak bark extracts showed clear antibacterial activities against most bacteria tested, with the highest antibacterial activities in the extracts of Q. robur . In addition, the three extracts showed higher antibacterial activities against Pseudomonas aeruginosa , Micrococcus flavus , and Escherichia coli compared to that of other bacteria. There were strong antifungal activities against some fungi, such as Aspergillus flavus , Penicillium funiculosum , and Penicillium ochrochloron . There were also noticeable anticancer activities against MCF-7, HeLa, Jurkat, and HT-29 cell lines, with the highest anticancer activity in the extracts of Q. robur . This is the first study that reveals not only novel sources of important polyphenols (e.g. ellagic acid) in Q . robur , Q. macrocarpa and Q. acutissima bark but also their anticancer activities against diverse cancer cell lines. Competing Interests: The authors declare no conflict of interest
Databáze:	MEDLINE
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