Comparison of Short- And Long-Term Variability in Standard Perimetry and Spectral Domain Optical Coherence Tomography in Glaucoma.

Autor: Urata CN; Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Mariottoni EB; Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Jammal AA; Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Ogata NG; Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Thompson AC; Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Berchuck SI; Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North Carolina, USA; Department of Statistical Science and Forge, Duke University, Durham, North Carolina, USA., Estrela T; Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North Carolina, USA., Medeiros FA; Duke Eye Center, Department of Ophthalmology, Duke University, Durham, North Carolina, USA. Electronic address: felipe.medeiros@duke.edu.
Jazyk: angličtina
Zdroj: American journal of ophthalmology [Am J Ophthalmol] 2020 Feb; Vol. 210, pp. 19-25. Date of Electronic Publication: 2019 Nov 09.
DOI: 10.1016/j.ajo.2019.10.034
Abstrakt: Purpose: To assess short- and long-term variability on standard automated perimetry (SAP) and spectral domain optical coherence tomography (SD-OCT) in glaucoma.
Design: Prospective cohort.
Methods: Ordinary least squares linear regression of SAP mean deviation (MD) and SD-OCT global retinal nerve fiber layer (RNFL) thickness were fitted over time for sequential tests conducted within 5 weeks (short-term testing) and annually (long-term testing). Residuals were obtained by subtracting the predicted and observed values, and each patient's standard deviation (SD) of the residuals was used as a measure of variability. Wilcoxon signed-rank test was performed to test the hypothesis of equality between short- and long-term variability.
Results: A total of 43 eyes of 43 glaucoma subjects were included. Subjects had a mean 4.5 ± 0.8 SAP and OCT tests for short-term variability assessment. For long-term variability, the same number of tests were performed and results annually collected over an average of 4.0 ± 0.8 years. The average SD of the residuals was significantly higher in the long-term than in the short-term period for both tests: 1.05 ± 0.70 dB vs. 0.61 ± 0.34 dB, respectively (P < 0.001) for SAP MD and 1.95 ± 1.86 μm vs. 0.81 ± 0.56 μm, respectively (P < 0.001) for SD-OCT RNFL thickness.
Conclusions: Long-term variability was higher than short-term variability on SD-OCT and SAP. Because current event-based algorithms for detection of glaucoma progression on SAP and SD-OCT have relied on short-term variability data to establish their normative databases, these algorithms may be underestimating the variability in the long-term and thus may overestimate progression over time.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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