Chemical Composition and in Vitro Cytotoxic Screening of Sixteen Commercial Essential Oils on Five Cancer Cell Lines.
| Autor: | Najar B; Dipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126, Pisa, Italy., Shortrede JE; Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, 56126, Pisa, Italy., Pistelli L; Dipartimento di Farmacia, Università di Pisa, Via Bonanno 33, 56126, Pisa, Italy., Buhagiar J; Department of Biology, University of Malta, Msida MSD, 2080, Malte.; Argotti Botanic Garden & Resource Center, Triq Sarria, Il-, Furjana FRN, 1553, Malte. |
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| Jazyk: | angličtina |
| Zdroj: | Chemistry & biodiversity [Chem Biodivers] 2020 Jan; Vol. 17 (1), pp. e1900478. Date of Electronic Publication: 2019 Dec 12. |
| DOI: | 10.1002/cbdv.201900478 |
| Abstrakt: | The in vitro cytotoxic activity on human cancer cell lines of sixteen commercial EOs such as Aloysia citriodora, Boswellia sacra, Boswellia serrata, Cinnamomum zeylanicum, Cistus ladanifer, Citrus × aurantium, Citrus limon, Citrus sinensis, Cymbopogon citratus, Foeniculum vulgare, Illicium verum, Litsea cubeba, Satureja montana, Syzygium aromaticum, Thymus capitatus and Thymus vulgaris was performed using the MTT reduction assay. The screening was carried out on human cancer cells of breast adenocarcinoma (MCF7, T47D and MDA-MB-231), chronic myelogenous erythroleukemia (K562) and neuroblastoma cell lines (SH-SY5Y). C. zeylanicum and L. cubeba EOs were the most active on almost all the cell lines studied and thus could be promising as an anticancer agent. These two species showed a difference in their composition even though they belong to the Lauraceae family. Almost 57 % of the true cinnamon composition was made of (E)-cinnamaldehyde, while L. cubeba showed citral as the major compound (68.9 %). The K562 cells were the most sensitive to these oils with an IC (© 2019 Wiley-VHCA AG, Zurich, Switzerland.) |
| Databáze: | MEDLINE |
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