Consumption of a high-fat diet does not potentiate the deleterious effects on lipid and protein levels and body development in rats subjected to maternal protein restriction.

Autor: Barbosa SDS; Nucleus of Physical Education and Sport Sciences, Universidade Federal de Pernambuco (CAV/UFPE), Vitória de Santo Antão, Brazil., Mello APDFAC; Nucleus of Physical Education and Sport Sciences, Universidade Federal de Pernambuco (CAV/UFPE), Vitória de Santo Antão, Brazil., Nogueira VO; Nucleus of Physical Education and Sport Sciences, Universidade Federal de Pernambuco (CAV/UFPE), Vitória de Santo Antão, Brazil., da Silva IF; Nucleus of Physical Education and Sport Sciences, Universidade Federal de Pernambuco (CAV/UFPE), Vitória de Santo Antão, Brazil., de Melo PED; Nucleus of Physical Education and Sport Sciences, Universidade Federal de Pernambuco (CAV/UFPE), Vitória de Santo Antão, Brazil., Dos Santos CR; Nucleus of Public Health, Centro Acadêmico de Vitória, Universidade Federal de Pernambuco (CAV/UFPE), Vitória de Santo Antão, Brazil., Costa-Silva JHD; Nucleus of Physical Education and Sport Sciences, Universidade Federal de Pernambuco (CAV/UFPE), Vitória de Santo Antão, Brazil., Araújo AV; Nucleus of Public Health, Centro Acadêmico de Vitória, Universidade Federal de Pernambuco (CAV/UFPE), Vitória de Santo Antão, Brazil.
Jazyk: angličtina
Zdroj: Clinical and experimental pharmacology & physiology [Clin Exp Pharmacol Physiol] 2020 Mar; Vol. 47 (3), pp. 412-421. Date of Electronic Publication: 2019 Dec 17.
DOI: 10.1111/1440-1681.13210
Abstrakt: Maternal undernutrition may cause injuries in several organs of the offspring, as well as lead to diseases in adulthood. Obesity and/or the consumption of a high-fat diet may also induce metabolic and cardiorespiratory diseases. We hypothesized that the consumption of a post-weaning high-fat diet would potentiate the deleterious effects of maternal protein undernutrition. This study evaluated the effects of the association of a low-protein diet during gestation and lactation with a post-weaning high-fat diet on the biochemical and ventilatory parameters of rats. Male Wistar rats from mothers who received a low-protein (9% of protein) or normoprotein diet during pregnancy and lactation received a high-fat (32% of total kilocalories from lipids) or a normal fat diet after weaning. Mass gain and somatic growth of the offspring were monitored. Also examined were biochemical chemical parameters and respiratory frequency, tidal volume (volume of air displaced in each normal respiratory cycle when extra effort is not applied), and pulmonary ventilation. Offspring from undernourished mothers presented lower birth weight (P = .0225), which remained until the end of lactation (P < .01). The rats that consumed high-fat diet and had been submitted to maternal undernutrition presented higher tidal volume when compared to the ones that consumed control diet at the 21st day of life (P ˂ .05). At 30 and 90 days, no further ventilatory changes were observed. Our data show that the consumption of a high-fat diet post-weaning did not seem to potentiate the changes induced by maternal undernutrition.
(© 2019 John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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