Surveillance summary of hospitalized pediatric enterovirus D68 cases in Canada, September 2014.

Autor:	Edwin JJ; Centre for Public Health Infrastructure, Public Health Agency of Canada, Ottawa, ON., Domingo FR; Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON., Booth TF; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB., Mersereau T; Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON., Skowronski DM; British Columbia Centre for Disease Control, Vancouver, BC., Chambers C; British Columbia Centre for Disease Control, Vancouver, BC., Simmonds K; Alberta Health, Edmonton, AB., Scott AN; Alberta Health, Edmonton, AB., Winter AL; Public Health Ontario, Toronto, ON., Peci A; Public Health Ontario, Toronto, ON., Gubbay J; Public Health Ontario, Toronto, ON., Drews SJ; Alberta Provincial Laboratory for Public Health, Edmonton and Calgary, AB., Krajden M; British Columbia Centre for Disease Control, Vancouver, BC., Karnauchow T; Children's Hospital of Eastern Ontario, Ottawa, ON., Smieja M; Hamilton Regional Laboratory Medicine Program, Hamilton, ON., Rempel S; Centre for Public Health Infrastructure, Public Health Agency of Canada, Ottawa, ON., Murti M; Fraser Health Authority, Surrey, BC., Pollock S; Interior Health Authority, Kelowna, BC., Gustafson R; Vancouver Coastal Health Authority, Vancouver, BC., Hoyano D; Vancouver Island Health Authority, Victoria, BC., Allison S; Northern Health Authority, Prince George, BC., Fathima S; Alberta Provincial Laboratory for Public Health, Edmonton and Calgary, AB., Pabbaraju K; Alberta Provincial Laboratory for Public Health, Edmonton and Calgary, AB., Wong S; Alberta Provincial Laboratory for Public Health, Edmonton and Calgary, AB., Tellier R; Alberta Provincial Laboratory for Public Health, Edmonton and Calgary, AB., Tipples G; Alberta Provincial Laboratory for Public Health, Edmonton and Calgary, AB., Gad RR; New Brunswick Department of Health, Fredericton, NB., Mukhi SN; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB., Jafari Y; Northwest Territories Health and Social Services, Yellowknife, NT., Grudeski E; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB., McDermid A; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB., Wong T; Centre for Immunization and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON.
Jazyk:	angličtina
Zdroj:	Canada communicable disease report = Releve des maladies transmissibles au Canada [Can Commun Dis Rep] 2015 Feb 20; Vol. 41 (Suppl 1), pp. 2-8. Date of Electronic Publication: 2015 Feb 20 (Print Publication: 2015).
DOI:	10.14745/ccdr.v41is1a01
Abstrakt:	Background: Enterovirus D68 (EV-D68) has been detected infrequently and has not been associated with severe disease in Canada. In the early fall of 2014, following an unusual case increase in the United States, clusters of EV-D68 among children and some adults manifesting severe symptoms were reported in Canada. Objective: To provide an initial epidemiological summary of pediatric cases hospitalized with EV-D68 in Canada. Methods: A time-limited surveillance pilot was conducted collecting information on pediatric cases (less than 18 years of age) hospitalized with EV-D68 between September 1 and 30, 2014. Results: In total, 268 cases were reported from Ontario (n=210), Alberta (n=45), and British Columbia (n=13). Of the 268 reported cases, 64.9% (n=174) were male; the sex difference was statistically significant (p<0.01). Age was reported for 255 cases, with a mean age for males of 5.4 years and for females of 5.3 years. For cases with data available, 6.8% (18/266) were admitted to an intensive care unit. Of those where clinical illness was recorded, respiratory illness alone was present in 98.3% (227/231), neurologic illness alone was present in 0.4% (n=1), and both illnesses were present in 0.9% of cases (n=2); cases with neither respiratory nor neurologic illness were rare (n=1). Of the 90 cases with additional clinical information available, 43.3% were reported as having asthma. No deaths were reported among the 268 cases. Conclusion: The EV-D68 outbreak in Canada in September 2014 represents the beginning of a novel outbreak associated with severe illness in children. These findings provide the first epidemiological summary of severe cases of EV-D68 as an emergent respiratory pathogen in Canada. The continued investigation of this pathogen is necessary to build on these results and capture the full spectrum of associated illness. Competing Interests: Conflict of interest: None
Databáze:	MEDLINE
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