Maternal stress in sheep during late pregnancy influences sperm quality in early puberty of the offspring.

Autor: Henrique FL; Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil., Bezerra HVA; Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil., Polato HZ; Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil., Fernandes AC; Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil., Zanella AJ; Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil., Alves MBR; Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil., Celeghini ECC; Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil., Batissaco L; Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil., Strefezzi RF; Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil., Pulido-Rodríguez LF; Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil., Hooper HB; Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil., Titto CG; Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São Paulo, Av. Duque de Caxias Norte, 225, Campus Fernando Costa, Pirassununga, SP, 13635-900, Brazil. Electronic address: crisgtitto@usp.br.
Jazyk: angličtina
Zdroj: Theriogenology [Theriogenology] 2020 Mar 15; Vol. 145, pp. 158-166. Date of Electronic Publication: 2019 Oct 15.
DOI: 10.1016/j.theriogenology.2019.10.008
Abstrakt: Stress at the end of sheep gestation can damage the reproductive development of young males. The aim of the present study was to evaluate the effects of LPS administration in the last third of sheep pregnancy on the reproductive parameters of prepubertal rams. Thirty-six pregnant nulliparous ewes (12 ± 2 months old; 45 ± 6 kg) were assigned to two treatments, LPS (E. coli; 0.8 μg kg -1 ) and control (placebo/saline) administered in late pregnancy (120 days post-conception). The animals gave birth to 17 male lambs (11 LPS; 8 control). Reproductive development of the young rams was analyzed from 5 to 12 months of age. A completely randomized design in double factorial scheme was used. The data were analyzed by analysis of variance. The model included treatment (LPS; control), age as main effects and their interactions, and the animal as a repeated measure. Means were compared by the PDIFF-SAS (Pr > |t|) at P < 0.05. An effect of age was observed for scrotal circumference, testicular consistency, homogeneity of testicular parenchyma, vascularization, semen quantity and quality, and blood testosterone concentration (P < 0.05). LPS increased sperm defects (P < 0.05) but an interaction with age was not observed (P > 0.05) with higher abnormalities only during months 8 and 9 (P < 0.05) and not thereafter. In summary, LPS did not cause long-term damage to testicular morphology analyzed from the onset of puberty to sexual maturity. However, LPS treatment affected sperm morphology during early puberty of the offspring.
(Copyright © 2019 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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