The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB.

Autor: Formicola B; School of Medicine and Surgery, University of Milano-Bicocca, Via Raoul Follereau 3, 20854, Vedano al Lambro, MB, Italy. b.formicola@campus.unimib.it., Dal Magro R; School of Medicine and Surgery, University of Milano-Bicocca, Via Raoul Follereau 3, 20854, Vedano al Lambro, MB, Italy., Montefusco-Pereira CV; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Saarland University, 66123, Saarbrücken, Germany., Lehr CM; Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland, Saarland University, 66123, Saarbrücken, Germany., Koch M; Leibniz Institute for New Materials, Campus D2 2, 66123, Saarbrücken, Germany., Russo L; Bio Organic Chemistry Laboratory, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Via Raoul Follereau 3, 20854, Vedano al Lambro, MB, Italy., Grasso G; Istituto Dalle Molle di Studi Sull'Intelligenza Artificiale (IDSIA), Scuola Universitaria Professionale Della Svizzera Italiana (SUPSI), Università Della Svizzera Italiana (USI), Manno, Switzerland., Deriu MA; Department of Mechanical and Aerospace Engineering (DIMEAS), Politecnico di Torino, Corso Duca degli Abruzzi 24, 10128, Turin, Italy., Danani A; Istituto Dalle Molle di Studi Sull'Intelligenza Artificiale (IDSIA), Scuola Universitaria Professionale Della Svizzera Italiana (SUPSI), Università Della Svizzera Italiana (USI), Manno, Switzerland., Bourdoulous S; U1016, Institut Cochin, Inserm, Paris, France., Re F; School of Medicine and Surgery, University of Milano-Bicocca, Via Raoul Follereau 3, 20854, Vedano al Lambro, MB, Italy.
Jazyk: angličtina
Zdroj: Journal of nanobiotechnology [J Nanobiotechnology] 2019 Nov 11; Vol. 17 (1), pp. 115. Date of Electronic Publication: 2019 Nov 11.
DOI: 10.1186/s12951-019-0546-3
Abstrakt: We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood-brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-loaded liposomes across the BBB, keeping the anti-tumour activity of the drug loaded: mApoE acts promoting cellular uptake, while ClTx promotes exocytosis of liposomes.
Databáze: MEDLINE
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