Zika virus infection: A correlation between prenatal ultrasonographic and postmortem neuropathologic changes.

Autor: Gutiérrez Sánchez LA; School of Medicine, Health Faculty, Universidad Industrial de Santander, Bucaramanga, Colombia.; Department of Gynecology and Obstetrics, Hospital Universitario de Santander, Bucaramanga, Colombia., Sandoval Martínez DK; School of Medicine, Health Faculty, Universidad Industrial de Santander, Bucaramanga, Colombia.; Department of Pathology, Hospital Universitario de Santander, Bucaramanga, Colombia., Díaz-Martínez LA; School of Medicine, Health Faculty, Universidad Industrial de Santander, Bucaramanga, Colombia., Becerra Mojica CH; School of Medicine, Health Faculty, Universidad Industrial de Santander, Bucaramanga, Colombia.; Department of Gynecology and Obstetrics, Hospital Universitario de Santander, Bucaramanga, Colombia.
Jazyk: angličtina
Zdroj: Neuropathology : official journal of the Japanese Society of Neuropathology [Neuropathology] 2019 Dec; Vol. 39 (6), pp. 434-440. Date of Electronic Publication: 2019 Nov 11.
DOI: 10.1111/neup.12603
Abstrakt: This study presents a correlation between prenatal ultrasonographic images and neuropathologic findings of postmortem tissue samples from five confirmed cases of perinatal Zika virus (ZIKV) infection belonging to the cohort of the ZEN Initiative in Bucaramanga, Colombia. Deaths occurred between June 2016 and March 2017. Mothers consulted with ZIKV infection clinical manifestations or fetal central nervous system (CNS) abnormalities or both. A detailed ultrasound scan and neurosonographic protocol was performed by maternal fetal specialists. Perinatal autopsies were performed following the Colombian National Health Institute's ZIKV protocol. The autopsies were from two fetal deaths, and three early neonatal deaths. Gestational age was between 26 2/7 and 38 2/7 weeks. Two cases were classified as mild microcephaly. Few findings by ultrasound and pathology were found in case 1 because it was a late infection; the other cases presented findings corresponding to congenital Zika syndrome: craniofacial malformations, cerebellar hypoplasia, anomalies of the corpus callosum and ventriculomegaly, all confirmed in autopsy specimens. By ultrasonography, hyperechogenicities were seen in several brain structures, which correspond to cortical and periventricular calcifications, subependymal glial reactivity and perivascular rings. The ultrasound and pathological findings show a wide spectrum of CNS anomalies that confirm the neurotropic effect of the ZIKV, recognizing the neuroimaging findings of this disease (unilateral ventriculomegaly, alterations in the corpus callosum and cerebellum, and calcifications) are highly suggestive of ZIKV infection.
(© 2019 Japanese Society of Neuropathology.)
Databáze: MEDLINE
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