Sex differences in the interaction of short-term particulate matter exposure and psychosocial stressors on C-reactive protein in a Puerto Rican cohort.

Autor:	Fuller CH; Georgia State University School of Public Health, Department of Population Health Sciences, Atlanta, GA, USA., Appleton AA; University at Albany School of Public Health, Department of Epidemiology and Biostatistics, Rensselaer, NY, USA., Bulsara PJ; Georgia State University School of Public Health, Department of Population Health Sciences, Atlanta, GA, USA., O'Neill MS; University of Michigan School of Public Health, Departments of Environmental Health Sciences and Epidemiology, Ann Arbor, MI, USA., Chang HH; Emory University, Rollins School of Public Health, Department of Biostatistics, Atlanta, GA, USA., Sarnat JA; Emory University, Rollins School of Public Health, Department of Environmental Health, Atlanta, GA, USA., Falcón LM; University of Massachusetts Lowell, Fine Arts, Humanities and Social Sciences, Lowell, MA, USA., Tucker KL; University of Massachusetts Lowell, Department of Biomedical and Nutritional Sciences, Lowell, MA, USA., Brugge D; University of Connecticut Department of Community Medicine and Health Care, Farmington, CT, USA.; Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA.
Jazyk:	angličtina
Zdroj:	SSM - population health [SSM Popul Health] 2019 Oct 13; Vol. 9, pp. 100500. Date of Electronic Publication: 2019 Oct 13 (Print Publication: 2019).
DOI:	10.1016/j.ssmph.2019.100500
Abstrakt:	There is substantial evidence linking particulate matter air pollution with cardiovascular morbidity and mortality. However, health disparities between populations may exist due to imprecisely defined non-innate susceptibility factors. Psychosocial stressors are associated with cardiovascular disease and may increase non-innate susceptibility to air-pollution. We investigated whether the association between short-term changes in ambient particulate matter and cardiovascular health risk differed by psychosocial stressors in a Puerto Rican cohort, comparing women and men. We used data from the Boston Puerto Rican Health Study (BPRHS), a longitudinal study of cardiovascular health among adults, collected between 2004 and 2013. We used mixed effect models to estimate the association of current-day ambient particle number concentration (PNC) on C-reactive protein (CRP), a marker of systemic inflammation, and effect modification by psychosocial stressors (depression, acculturation, perceived stress, discrimination, negative life events and a composite score). Point estimates of percent difference in CRP per interquartile range change in PNC varied among women with contrasting levels of stressors: negative life events (15.7% high vs. 6.5% low), depression score (10.6% high vs. 4.6% low) and composite stress score (16.2% high vs. 7.0% low). There were minimal differences among men. For Puerto Rican adults, cardiovascular non-innate susceptibility to adverse effects of ambient particles may be greater for women under high stress. This work contributes to understanding health disparities among minority ethnic populations. Competing Interests: The authors declare no conflicts of interest. (© 2019 The Authors. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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