Clonal relationship of marginal zone lymphoma and diffuse large B-cell lymphoma in Sjogren's syndrome patients: case series study and review of the literature.

Autor: Gorodetskiy VR; Department of Intensive Methods of Therapy, V.A. Nasonova Research Institute of Rheumatology, Kashirskoye shosse 34A, Moscow, 115522, Russia. gorodetskiyblood@mail.ru., Probatova NA; Department of Pathology, N.N. Blokhin Russian Cancer Research Center, Kashirskoye shosse 24, Moscow, 115478, Russia., Radenska-Lopovok SG; Department of Pathology, I.M. Sechenov First Moscow State Medical University (Sechenov University), Trubetskaja str., 8-2, Moscow, 119991, Russia., Ryzhikova NV; Laboratory of Molecular Hematology, National Research Center for Hematology, Novy Zykovskiy Proezd, 4a, Moscow, 125167, Russia., Sidorova YV; Laboratory of Molecular Hematology, National Research Center for Hematology, Novy Zykovskiy Proezd, 4a, Moscow, 125167, Russia., Sudarikov AB; Laboratory of Molecular Hematology, National Research Center for Hematology, Novy Zykovskiy Proezd, 4a, Moscow, 125167, Russia.
Jazyk: angličtina
Zdroj: Rheumatology international [Rheumatol Int] 2020 Mar; Vol. 40 (3), pp. 499-506. Date of Electronic Publication: 2019 Nov 09.
DOI: 10.1007/s00296-019-04470-x
Abstrakt: The occurrence of diffuse large B-cell lymphoma (DLBCL) in the course of Sjogren's syndrome (SS) is considered to be equally related either to the development of DLBCL de novo or to the transformation from marginal zone lymphoma (MZL). However, the question of possible clonal relationship between MZL and DLBCL in the group of SS patients remains open. Here we present the data concerning 194 patients with lymphoma complicated SS followed up at Nasonova Research Institute of Rheumatology during the last 22 years. Molecular analysis of tumor cells was performed for 6 SS patients who had developed both MZL and DLBCL. To assess clonal relationship between each of the tumor pairs immunoglobulin heavy chain (IGH) gene rearrangements were identified according BIOMED-2 protocol by means of multiplex polymerase chain reaction followed by GeneScan fragment analysis. Despite different localization MZL and DLBCL were clonally related in five tumor pairs. The median time to transformation was 11 months (range 0-78 months). MZL and DLBCL were clonally related in most cases from our cohort of SS patients. No statistically significant difference in survival between patients with DLBCL transformed from MZL and patients with de novo DLBCL was found in the cohort of SS patients investigated.
Databáze: MEDLINE
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