Angular restriction fluorescence optical projection tomography to localize micrometastases in lymph nodes.

Autor:	Torres VC; Illinois Institute of Technology, Department of Biomedical Engineering, Chicago, Illinois, United States., Li C; Illinois Institute of Technology, Department of Biomedical Engineering, Chicago, Illinois, United States., He Y; Illinois Institute of Technology, Department of Biomedical Engineering, Chicago, Illinois, United States., Sinha L; Illinois Institute of Technology, Department of Biomedical Engineering, Chicago, Illinois, United States., Papavasiliou G; Illinois Institute of Technology, Department of Biomedical Engineering, Chicago, Illinois, United States., Sattar HA; University of Chicago, Department of Pathology, Chicago, Illinois, United States., Brankov JG; Illinois Institute of Technology, Department of Biomedical Engineering, Chicago, Illinois, United States.; Illinois Institute of Technology, Department of Electrical and Computer Engineering, Chicago, Illino, United States., Tichauer KM; Illinois Institute of Technology, Department of Biomedical Engineering, Chicago, Illinois, United States.
Jazyk:	angličtina
Zdroj:	Journal of biomedical optics [J Biomed Opt] 2019 Nov; Vol. 24 (11), pp. 1-4.
DOI:	10.1117/1.JBO.24.11.110501
Abstrakt:	Lymph node biopsy is a primary means of staging breast cancer, yet standard pathological techniques are time-consuming and typically sample less than 1% of the total node volume. A low-cost fluorescence optical projection tomography (OPT) protocol is demonstrated for rapid imaging of whole lymph nodes in three dimensions. The relatively low scattering properties of lymph node tissue can be leveraged to significantly improve spatial resolution of lymph node OPT by employing angular restriction of photon detection. It is demonstrated through porcine lymph node metastases models that simple filtered-backprojection reconstruction is sufficient to detect and localize 200-μm-diameter metastases (the smallest clinically significant) in 1-cm-diameter lymph nodes.
Databáze:	MEDLINE
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