| Autor: |
Salazar de Pablo G; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK., Vaquerizo Serrano JD; Psychiatry Department, School of Medicine, Hospital General Universitario Gregorio Marañón, Universidad Complutense (UCM), Madrid, Spain., Gómez Vallejo S; Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK., Sánchez Cerezo J; Psychiatry Department, School of Medicine, Hospital General Universitario Gregorio Marañón, Universidad Complutense (UCM), Madrid, Spain., Moreno Ruiz C; Child and Adolescent Psychiatry Department, School of Medicine, Hospital General Universitario Gregorio Marañón, Universidad Complutense (UCM), IiSGM, CIBERSAM, Madrid, Spain. cmoreno@hggm.es. |
| Abstrakt: |
Developmental psychopathology studies the basic mechanisms, including not only biological factors but also environmental and social factors that may interact with them, by means of which developmental pathways deviate toward pathological or typical outcomes. Family studies conducted during the last century show substantial evidence of heritability among psychiatric disorders. Besides, a large number of genes implicated in shaping the development of the central nervous system have been related to psychiatric conditions. In addition, there is a wide range of stressors and harmful agents that, when acting on sensitive developmental periods, might damage brain function and generate or precipitate psychopathology over time. All these factors have the potential to change the way disorders with a neurodevelopmental origin are expressed, including their age of appearance and clinical manifestations. Both symptoms and social impairment need to be considered in clinical evaluations, as treatment is unlikely to be effective if the problem has not been characterized correctly or if the patients' particular characteristics, which change throughout development, are not taken into consideration. |
