Lipid and metabolic profiles in female dogs with mammary carcinoma receiving dietary fish oil supplementation.

Autor: Costa-Santos K; Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia, Salvador, Bahia, 40170-110, Brazil.; Instituto Federal de Educação, Ciência e Tecnologia do Sertão Pernambucano, Santa Maria da Boa Vista, Pernambuco, 56380-000, Brazil., Damasceno K; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil., Portela RD; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, 40110-100, Brazil., Santos FL; Universidade Federal do Recôncavo da Bahia, Santo Antônio de Jesus, Bahia, 44570-000, Brazil., Araújo GC; Universidade do Estado da Bahia, Salvador, Bahia, 41195-001, Brazil., Martins-Filho EF; Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia, Salvador, Bahia, 40170-110, Brazil., Silva LP; Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia, Salvador, Bahia, 40170-110, Brazil., Barral TD; Instituto de Ciências da Saúde, Universidade Federal da Bahia, Salvador, Bahia, 40110-100, Brazil., Santos SA; Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia, Salvador, Bahia, 40170-110, Brazil., Estrela-Lima A; Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia, Salvador, Bahia, 40170-110, Brazil. alestrela@gmail.com.
Jazyk: angličtina
Zdroj: BMC veterinary research [BMC Vet Res] 2019 Nov 08; Vol. 15 (1), pp. 401. Date of Electronic Publication: 2019 Nov 08.
DOI: 10.1186/s12917-019-2151-y
Abstrakt: Background: Dyslipidemias induce angiogenesis and accelerate the development and in vitro growth of breast tumors. The aim of this study was to assess the lipid and metabolic profile of female dogs with mammary carcinomas and their correlations with body condition score and degree of tumor malignancy, as well as to study the effect of dietary fish oil supplementation on these animals.
Results: Overweight or obese dogs had more aggressive carcinomas and higher triglyceride (p = 0.0363), VLDL (p = 0.0181), albumin (p = 0.0188), globulin (p = 0.0145) and lactate (p = 0.0255) concentrations. There was no change in the lipid profile after supplementation with fish oil at any concentration. However, in relation to the metabolic profile, glucose (p = 0.0067), total protein (p = 0.0002) and globulin (p = 0.0002) concentrations were increased when 90% omega-3 fish oil was used as a dietary supplement.
Conclusion: Obese dogs showed altered lipid and metabolic profiles and more aggressive tumors, suggesting an important relationship between dyslipidemia and tumor aggressiveness. Supplementation with fish oil, rich in omega-3 fatty acids, may alter metabolic parameters in cancer patients.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje