Effect of different healing stages on stable isotope ratios in skeletal lesions.

Autor: Curto A; Human Osteology Lab, Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK.; Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal., Mahoney P; Human Osteology Lab, Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK., Maurer AF; HERCULES Laboratory, Évora University, Évora, Portugal., Barrocas-Dias C; HERCULES Laboratory, Évora University, Évora, Portugal.; School of Sciences and Technology, Chemistry Department, University of Évora, Évora, Portugal., Fernandes T; Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal.; School of Sciences and Technology, Biology Department, University of Évora, Pólo da Mitra, Évora, Portugal., Fahy GE; Human Osteology Lab, Skeletal Biology Research Centre, School of Anthropology and Conservation, University of Kent, Canterbury, UK.
Jazyk: angličtina
Zdroj: American journal of physical anthropology [Am J Phys Anthropol] 2020 Feb; Vol. 171 (2), pp. 285-297. Date of Electronic Publication: 2019 Nov 08.
DOI: 10.1002/ajpa.23958
Abstrakt: Introduction: Physiological stress is one of the various factors that can have an impact on stable isotope ratios. However, its effect on bone collagen stable isotope ratios is still not fully understood. This study aims to build on previous research on how different disease stages may affect bone collagen stable isotope ratios.
Materials and Methods: Carbon (δ 13 C) and nitrogen (δ 15 N) isotope ratios were assessed in 33 skeletons that retained evidence of infectious disease and healed fractures. Samples were taken from active lesions (long bones n = 14; ribs n = 4), healed lesions (long bones n = 10; ribs n = 9), or a fracture callus (long bones n = 9; ribs n = 3). Results were compared to stable isotope ratios calculated for regions on these bones that did not retain evidence of disease or fracture.
Results: Long bones with active lesions had a significantly higher average δ 15 N (δ 15 N = 11.1 ± 0.9‰) compared to those without lesions (δ 15 N = 10.7 ± 0.7‰; p = .02), while fracture calluses showed the largest range for both δ 15 N and δ 13 C. There were no significant differences in stable isotope ratios when compared between nonlesion and lesion sites in the ribs.
Discussion: The increase in δ 15 N seen in active lesions, when compared with δ 15 N from nonlesion regions on the same long bone, may be a consequence of altered protein metabolism. The high variability of δ 15 N and δ 13 C in fractures may be related to different healing stages of the calluses. This study suggests that stable isotope data can contribute information about diseases in the past, as well as an individual's response to diseases in the absence of modern medicine and antibiotics.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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