Utility of leucocytes, inflammatory markers and pancreatic enzymes as indicators of gangrenous cholecystitis.

Autor:	Raffee L; Accident and Emergency Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan laraffee5@just.edu.jo., Kuleib S; Accident and Emergency Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.; Accident and Emergency, King Abdullah University Hospital, Irbid, Jordan., Oteir A; Allied Medical Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.; Community Emergency Health and Paramedic Practice, Monash University, Peninsula Campus, Frankston, Victoria, Australia., Kewan T; Family Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan., Alawneh K; Diagnostic Radiology and Nuclear Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan., Beovich B; Community Emergency Health and Paramedic Practice, Monash University, Peninsula Campus, Frankston, Victoria, Australia., Williams B; Community Emergency Health and Paramedic Practice, Monash University, Peninsula Campus, Frankston, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	Postgraduate medical journal [Postgrad Med J] 2020 Mar; Vol. 96 (1133), pp. 134-138. Date of Electronic Publication: 2019 Nov 07.
DOI:	10.1136/postgradmedj-2019-137095
Abstrakt:	Background: Acute cholecystitis is an emergency condition. If not promptly diagnosed and properly managed, the complication of gangrenous cholecystitis may develop, which may be a life-threatening complication. Objectives: The study aims to examine various characteristics and physiological parameters in patients diagnosed with acute cholecystitis to evaluate if significant predictive factors exist for the differential diagnosis of gangrenous cholecystitis. Materials and Methods: This was a retrospective study included patients with acute cholecystitis diagnosis, who presented to 'blinded for peer review' from 1 January 2010 to 1 January 2017. Parameters evaluated included liver function tests, complete cell count, C reactive protein, erythrocyte sedimentation rate (ESR), amylase and lipase levels, as well as medical history, and presenting clinical signs. Cases were divided according to whether or not there was a histopathological diagnosis of gangrenous cholecystitis. Results: A total of 186 (54.5%) female and 155 (45.5%) male cases were examined. Patients with gangrenous cholecystitis tended to be male, showed a significantly higher white cell count, higher neutrophil percentage, lower lymphocyte percentage and higher ESR compared with patients without gangrenous cholecystitis. However, serum amylase and lipase demonstrated no differential diagnostic utility CONCLUSION: Male patients with a high ESR level, high total leucocyte count with a relative high proportion of neutrophils and a low proportion of lymphocytes were found to be at increased risk of the presence of gangrenous cholecystitis. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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