Microglial activation in schizophrenia: Is translocator 18 kDa protein (TSPO) the right marker?

Autor: Sneeboer MAM; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University (BCRM-UMCU-UU), 3584, CG, Utrecht, the Netherlands; Department of Translational Neuroscience (BCRM-UMCU-UU), 3584, CG, Utrecht, the Netherlands., van der Doef T; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University (BCRM-UMCU-UU), 3584, CG, Utrecht, the Netherlands., Litjens M; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University (BCRM-UMCU-UU), 3584, CG, Utrecht, the Netherlands; Department of Translational Neuroscience (BCRM-UMCU-UU), 3584, CG, Utrecht, the Netherlands., Psy NBB; Netherlands Brain Bank for Psychiatry, Meibergdreef 47, 1105, BA, Amsterdam, the Netherlands., Melief J; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University (BCRM-UMCU-UU), 3584, CG, Utrecht, the Netherlands., Hol EM; Department of Translational Neuroscience (BCRM-UMCU-UU), 3584, CG, Utrecht, the Netherlands; Neuroimmunology, Netherlands Institute for Neuroscience, An Institute of the Royal Academy of Arts and Sciences, 1105, BA, Amsterdam, the Netherlands., Kahn RS; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University (BCRM-UMCU-UU), 3584, CG, Utrecht, the Netherlands; Department of Psychiatry, Icahn School of Medicine, New York, USA; Mental Illness Research, Education and Clinical Center (MIRECC), James J Peters VA Medical Center, Bronx, NY, USA., de Witte LD; Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University (BCRM-UMCU-UU), 3584, CG, Utrecht, the Netherlands; Department of Psychiatry, Icahn School of Medicine, New York, USA; Mental Illness Research, Education and Clinical Center (MIRECC), James J Peters VA Medical Center, Bronx, NY, USA. Electronic address: lotje.dewitte@mssm.edu.
Jazyk: angličtina
Zdroj: Schizophrenia research [Schizophr Res] 2020 Jan; Vol. 215, pp. 167-172. Date of Electronic Publication: 2019 Nov 04.
DOI: 10.1016/j.schres.2019.10.045
Abstrakt: Positron emission tomography (PET) with translocator 18 kDa protein (TSPO) radioligands has frequently been used to investigate microglial activation in schizophrenia in vivo. However, the specificity of this marker is increasingly debated. Here we show that TSPO expression is 1) not increased in postmortem brain tissue of schizophrenia patients; 2) not correlated with expression of microglial activation markers; 3) not restricted to microglia; and 4) not upregulated in ex vivo activated human primary microglia. Our data are in line with recent reports showing that TSPO expression is not increased in schizophrenia and that it is not a specific marker for activated microglia. This study emphasizes the need for further development of tracers to study the role of microglial activation in schizophrenia and other diseases.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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