Expeditious Access to Functionalized Tricyclic Pyrrolo-Pyridones via Tandem or Sequential C-N/C-C Bond Formations.
| Autor: | Fillery SM; Medicinal Chemistry, Oncology R&D , AstraZeneca, Cambridge , U.K., Gregson CL; Medicinal Chemistry, Oncology R&D , AstraZeneca, Cambridge , U.K., Guérot CM; Medicinal Chemistry, Oncology R&D , AstraZeneca, Cambridge , U.K. |
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| Jazyk: | angličtina |
| Zdroj: | Organic letters [Org Lett] 2019 Nov 15; Vol. 21 (22), pp. 9128-9132. Date of Electronic Publication: 2019 Nov 07. |
| DOI: | 10.1021/acs.orglett.9b03514 |
| Abstrakt: | The facile synthesis of both saturated and unsaturated tricyclic pyrrolo-pyridones starting from a single readily available, common monocyclic reagent has been developed. An intermolecular annulation via a tandem Buchwald-Hartwig/Heck reaction led to the synthesis of β-carbolinones. The analogous semisaturated tricyclic pyrrolo-pyridones were prepared in good to excellent yields by sequential Buchwald-Hartwig and Fischer indole reactions. The methods feature mild reaction conditions and good functional group tolerance. |
| Databáze: | MEDLINE |
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