Relación entre el índice lipoproteínas de baja densidad (LDL)/lipoproteínas de alta densidad (HDL) con enzimas antioxidantes y el índice oxLDL/HDL.

Autor:	Zamora-Ginez I; Benemérita Universidad Autónoma de Puebla, Facultad de Medicina, Puebla. México., Baez-Duarte BG; Benemérita Universidad Autónoma de Puebla, Facultad de Medicina, Puebla. México., Nieva-Vazquez A; Benemérita Universidad Autónoma de Puebla, Complejo Regional Sur, Puebla. México., García-Aragón KH; Universidad Autónoma del Estado de Morelos, Morelos. México., Monjaraz-Guzmán E; Benemérita Universidad Autónoma de Puebla, Unidad de Fisiología, Puebla. México., Mendoza-Carrera F; Instituto Mexicano del Seguro Social, Centro de Investigación Biomédica de Occidente, División de Medicina Molecular, Jalisco. México., Meneses-Zamora P; Benemérita Universidad Autónoma de Puebla, Facultad de Medicina, Puebla. México., Flores-Blanco CV; Benemérita Universidad Autónoma de Puebla, Facultad de Medicina, Puebla. México., Luna-De Jesús K; Instituto Politécnico Nacional, Centro de Investigación en Biotecnología Aplicada, Tlaxcala. México.
Jazyk:	angličtina
Zdroj:	Gaceta medica de Mexico [Gac Med Mex] 2019; Vol. 155 (5), pp. 487-492.
DOI:	10.24875/GMM.19004921
Abstrakt:	Introduction: The low-density lipoprotein (LDL)/high-density lipoprotein (HDL) index is a predictive factor for atherosclerosis, which is associated with oxidative modifications. Objective: To assess the association of the index with oxidative stress markers. Methods: 444 subjects were included and were clinically, anthropometrically and biochemically characterized; superoxide dismutase, glutathione peroxidase 3 (GPx3), magnesium and oxidized LDL (oxLDL) index (oxLDL/HDL) were quantified. Results: A decrease of 1.014 units in the LDL/HDL index was associated with a superoxide dismutase increase of 1 unit/mL (p = 0.030), while a decrease of 0.023 units was associated with a GPx3 increase of 1 nmol/min/mL (p < 0.0005). An increase of one unit in the index was associated with an increase of 0.831 in the oxLDL/HDL index (p < 0.05). After controlling for the effect of gender, age, smoking, obesity and insulin resistance, a reduction of 0.001 per index unit was associated with an increase of 1 µg/g of magnesium in the nails (p = 0.020). Conclusions: The LDL/HDL index shows an inverse relationship with the antioxidant status and a direct relationship with oxidation status, regardless of other cardiovascular and oxidative stress risk factors. (Copyright: © 2019 Permanyer.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu