| Autor: |
D Avila LSP; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, CE, Brazil., de Oliveira KA; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, CE, Brazil., de Abreu ES; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, CE, Brazil., Vasconcelos RP; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, CE, Brazil., Nascimento JF; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, CE, Brazil., Bezerra Pontes EO; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, CE, Brazil., Rickli S; Research Center on Obesity and Comorbidities, Campinas, SP, Brazil., Coelho de Souza AN; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, CE, Brazil., Leal Cardoso JH; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, CE, Brazil., Silveira LR; Research Center on Obesity and Comorbidities, Campinas, SP, Brazil., Carneiro EM; Research Center on Obesity and Comorbidities, Campinas, SP, Brazil., de Carvalho DP; Carlos Chagas Filho Institute of Biophysics, Rio de Janeiro, RJ, Brazil., Torres Leal FL; Center for Health Sciences, Teresina, PI, Brazil., de Oliveira AC; Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza, CE, Brazil. |
| Abstrakt: |
Studies have shown synergistic and independent effects of leucine and resveratrol (RSV) as possible therapeutic agents to ameliorate metabolic disorders. Thus, the objective of this study was to investigate the effects of supplementation with leucine and RSV, alone and in combination, on metabolic changes in white adipose tissue of neonatally STZ-induced diabetic rats. After weaning, the rats were treated with trans-resveratrol (0.6 mg/kg/dose) and/or leucine (1.35 mg/kg/dose) administered orally. The animals were euthanized at age 16 weeks for blood analyses. Subcutaneous (SC), periepididymal (PE) and retroperitoneal (RP) fat pads were weighed. Adipocytes from PE and RP pads were isolated for morphometric analysis. Long-term supplementation with RSV promoted adiposity recovery, prevented hypoinsulinemia and improved the metabolic profile of the diabetic rats. However, some of these effects were impaired when RSV was associated with leucine. The diabetic rats supplemented with leucine alone showed no significant improvement in metabolic disorders. |
