[Forty cases of neuromeningeal cryptococcosis diagnosed at the Mycology-Parasitology Department of the Ibn Sina hospital in Rabat, over a 21-year period].

Autor:	Bandadi FZ; Laboratoire Central de Parasitologie-Mycologie Médicale, Centre Hospitalier Ibn Sina de Rabat, Rue Lamfadel Cherkaoui, BP 6527, Rabat, Maroc.; Faculté de Médecine et de Pharmacie, Université Mohamed V, Avenue Mohammed Belarabi Elalaoui, BP 6203 Rabat-Instituts, Rabat, Maroc., Raiss C; Laboratoire Central de Parasitologie-Mycologie Médicale, Centre Hospitalier Ibn Sina de Rabat, Rue Lamfadel Cherkaoui, BP 6527, Rabat, Maroc.; Faculté de Médecine et de Pharmacie, Université Mohamed V, Avenue Mohammed Belarabi Elalaoui, BP 6203 Rabat-Instituts, Rabat, Maroc., Moustachi A; Laboratoire Central de Parasitologie-Mycologie Médicale, Centre Hospitalier Ibn Sina de Rabat, Rue Lamfadel Cherkaoui, BP 6527, Rabat, Maroc., Lyagoubi M; Laboratoire Central de Parasitologie-Mycologie Médicale, Centre Hospitalier Ibn Sina de Rabat, Rue Lamfadel Cherkaoui, BP 6527, Rabat, Maroc.; Faculté de Médecine et de Pharmacie, Université Mohamed V, Avenue Mohammed Belarabi Elalaoui, BP 6203 Rabat-Instituts, Rabat, Maroc., Aoufi S; Laboratoire Central de Parasitologie-Mycologie Médicale, Centre Hospitalier Ibn Sina de Rabat, Rue Lamfadel Cherkaoui, BP 6527, Rabat, Maroc.; Faculté de Médecine et de Pharmacie, Université Mohamed V, Avenue Mohammed Belarabi Elalaoui, BP 6203 Rabat-Instituts, Rabat, Maroc.
Jazyk:	francouzština
Zdroj:	The Pan African medical journal [Pan Afr Med J] 2019 Jul 23; Vol. 33, pp. 249. Date of Electronic Publication: 2019 Jul 23 (Print Publication: 2019).
DOI:	10.11604/pamj.2019.33.249.18011
Abstrakt:	Neuromeningeal cryptococcosis is a common and severe opportunistic fungal infection caused by the encapsulated yeast Cryptococcus neoformans. It commonly occurs in immunocompromised patients, in particular in subjects with advanced stage HIV while it is rare in immunocompetent patients. We report 40 cases of neuromeningeal cryptococcosis (NMC) diagnosed at the Mycology-Parasitology Department of the Ibn Sina hospital in Rabat, over a 21-year period (1993-2014). The diagnosis was based on nested-PCR-based assay for the detection of Cryptococcus neoformans after staining with China ink and culture on Sabouraud agar without actidione as well as on the identification of soluble cryptococcal antigens. Thirty-five patients had HIV infection, 2 patients were apparently immunocompetent and 3 were immunocompromised patients without HIV (30 men and 10 women). The average age of patients was 38 years; neuromeningeal cryptococcosis was indicative of HIV infection in 13 cases. In 22 cases it was a complication of AIDS. Twenty-seven patients of our series were treated with fluconazole monotherapy. Amphotericin B was used in 13 patients. Outcome was favorable in 13 patients (32.5%) while 3 patients had complications (7.5%). Eighteen patients died (45%) and 6 were lost to follow-up (15%). The tests to diagnose a Cryptococcus neoformans infection should be performed systematically in patients with neurological signs for early diagnosis. Competing Interests: Les auteurs ne déclarent aucun conflit d'intérêts. (© Fatima-Zahra Bandadi et al.)
Databáze:	MEDLINE
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