Changes in the distribution of etiologies of cirrhosis among patients referred for liver transplantation over 11 years in Iran.

Autor:	Mohagheghi S; Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran.; Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan., Khajehahmadi Z; Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan., Nikeghbalian S; Shiraz Transplant Center, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz., Alavian SM; Baqiyatallah Research Center for Gastroenterology and Liver Diseases, Baqiyatallah University of Medical Sciences, Tehran.; Middle East Liver Diseases (MELD) Center, Tehran., Doosti-Irani A; Department of Epidemiology, Research Center of Modeling of Non-Communicable Disease, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran., Khodadadi I; Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan., Karimi J; Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan., Sharafi H; Middle East Liver Diseases (MELD) Center, Tehran., Tavilani H; Department of Clinical Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan.
Jazyk:	angličtina
Zdroj:	European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2020 Jul; Vol. 32 (7), pp. 844-850.
DOI:	10.1097/MEG.0000000000001590
Abstrakt:	Background and Aim: Cirrhosis is a major public health problem worldwide. The prevalence of cirrhosis is various in different geographical regions. The aim of the present study was to determine the distribution of the etiologies of cirrhosis and their proportional changes through recent 11 years in Iran. Methods: In this retrospective, observational study, the data of cirrhotic patients who have been listed for liver transplantation in the Namazi Transplant Center (Shiraz, Iran) between January 2006 and December 2016 were analyzed. Demographic and clinical data of the patients including model for end-stage liver disease score, year of registration, and the etiologic diagnosis for each patient were retrieved. Results: The ratio of males to females was the highest (2.6:1) in patients with age over 50 years. Of 4891 patients, hepatitis B virus cirrhosis had the highest frequency (23.53%) and alcoholic cirrhosis had the lowest frequency (1.70%). The percentages of waiting list patients with hepatitis B virus (34.48%-17.48%) (P < 0.001), autoimmune hepatitis (12.64%-8.50%) (P = 0.037), and alcoholic cirrhosis (2.30%-1.10%) were decreased (P = 0.008) and the percentages of waiting list patients with cholestatic (12.64%-25.20%) and nonalcoholic steatohepatitis cirrhosis (0.77%-8.82%) were increased over 11 years (both P < 0.001). Hepatitis B virus and autoimmune hepatitis cirrhosis were the most prevalent in male and female patients, respectively. Conclusion: The results of the present study showed an increase in the frequency of cholestasis and nonalcoholic steatohepatitis cirrhosis and therefore it should be considered in the health policy implementation.
Databáze:	MEDLINE
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