Loss of adaptive capacity in asthmatic patients revealed by biomarker fluctuation dynamics after rhinovirus challenge.

Autor: Sinha A; Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Biomedical Engineering and University Children's Hospital, University of Basel, Basel, Switzerland., Lutter R; Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands.; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Xu B; University of Bordeaux, Inserm, Bordeaux Population Health Research Center, UMR 1219, Bordeaux, France., Dekker T; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Dierdorp B; Department of Experimental Immunology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Sterk PJ; Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands., Frey U; Department of Biomedical Engineering and University Children's Hospital, University of Basel, Basel, Switzerland., Eckert ED; Department of Biomedical Engineering and University Children's Hospital, University of Basel, Basel, Switzerland.
Jazyk: angličtina
Zdroj: ELife [Elife] 2019 Nov 05; Vol. 8. Date of Electronic Publication: 2019 Nov 05.
DOI: 10.7554/eLife.47969
Abstrakt: Asthma is a dynamic disease, in which lung mechanical and inflammatory processes interact in a complex manner, often resulting in exaggerated physiological, in particular, inflammatory responses to exogenous triggers. We hypothesize that this may be explained by respiratory disease-related systems instability and loss of adaptability to changing environmental conditions, manifested in highly fluctuating biomarkers and symptoms. Using time series of inflammatory (eosinophils, neutrophils, FeNO), clinical and lung function biomarkers (PEF, FVC,FEV 1 ), we estimated this loss of adaptive capacity (AC) during an experimental rhinovirus infection in 24 healthy and asthmatic human volunteers. Loss of AC was estimated by comparing similarities between pre- and post-challenge time series. Unlike healthy participants, the asthmatic's post-viral-challenge state resembled more other rhinovirus-infected asthmatics than their own pre-viral-challenge state (hypergeometric-test: p=0.029). This reveals loss of AC and supports the concept that in asthma, biological processes underlying inflammatory and physiological responses are unstable, contributing to loss of control.
Competing Interests: AS, RL, BX, TD, BD, PS, UF, EE No competing interests declared
(© 2019, Sinha et al.)
Databáze: MEDLINE
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