Denervation and senescence markers data from old rats with intrinsic differences in responsiveness to aerobic training.

Autor:	Brown LA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Judge JL; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Macpherson PC; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA., Koch LG; Department of Physiology and Pharmacology, The University of Toledo, Toledo, OH, USA., Qi NR; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Britton SL; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA., Brooks SV; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Jazyk:	angličtina
Zdroj:	Data in brief [Data Brief] 2019 Oct 10; Vol. 27, pp. 104570. Date of Electronic Publication: 2019 Oct 10 (Print Publication: 2019).
DOI:	10.1016/j.dib.2019.104570
Abstrakt:	The data described below is related to the manuscript "Late life maintenance and enhancement of functional exercise capacity in low and high responding rats after low intensity treadmill training" [1]. Rodents exhibit age-related declines in skeletal muscle function that is associated with muscle denervation and cellular senescence. Exercise training is a proven method to delay or even reverse some aging phenotypes, thus improving healthspan in the elderly. The beneficial effects of exercise to preserve muscle may be reliant on an individual's innate ability to adapt to aerobic training. To examine this question, we assessed aged rats that were selectively bred to be either minimally or highly responsive to aerobic exercise training. We specifically asked whether mild treadmill training initiated late in life would be beneficial to preserve muscle function in high response and low response trainer rats. We examined gene expression data on markers of denervation and senescence. We also evaluated measures of aerobic training and neuromuscular muscle function through work capacity, contractile properties, and endplate fragmentation for further analysis of the aging phenotype in older rodents. (© 2019 The Author(s).)
Databáze:	MEDLINE
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