Evaluation of the effects of bredemolic acid on selected markers of glucose homeostasis in diet-induced prediabetic rats.

Autor: Akinnuga AM; Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, South Africa., Siboto A; Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, South Africa., Khumalo B; Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, South Africa., Sibiya NH; Department of Pharmacy and Pharmacology, Rhodes University, Grahamstown, South Africa., Ngubane P; Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, South Africa., Khathi A; Department of Physiology, School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Westville, South Africa.
Jazyk: angličtina
Zdroj: Archives of physiology and biochemistry [Arch Physiol Biochem] 2022 Apr; Vol. 128 (2), pp. 306-312. Date of Electronic Publication: 2019 Nov 05.
DOI: 10.1080/13813455.2019.1680697
Abstrakt: Context: Pentacyclic triterpenes (such as maslinic acid) are natural anti-diabetic agents that ameliorate glucose metabolism in diet-induced prediabetes. However, the effects of bredemolic acid (BA), maslinic acid isomer, is yet unknown in prediabetic (PD) conditions.
Objectives: To investigate the effects of BA on some glucose homeostasis parameters in high-fat high-carbohydrate (HFHC) diet-induced PD rats.
Methods: Thirty-six (36) male rats (150-180 g) were divided into two groups, the normal diet (ND) non-prediabetic, NPD ( n = 6) and the HFHC diet PD groups ( n = 30). The PD animals were further sub-divided into five groups ( n = 6) where they were treated with BA for 12 weeks while monitoring changes in blood glucose, caloric intake, and body weight.
Results: Diet-induced prediabetes resulted in increased body weight, caloric intake, glycated haemoglobin, and glucose tolerance. BA treatment ameliorated glucose tolerance, lowered plasma insulin and increased expression of glucose transporter 4 (GLUT 4) in rats.
Conclusions: BA administration restored glucose homeostasis in diet-induced prediabetes regardless of diet intervention.
Databáze: MEDLINE
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