Alteration in inflammatory mediators in seriously eye-injured war veterans, long-term after sulfur mustard exposure.

Autor: Ghasemi H; Department of Ophthalmology, Shahed University, Tehran 3319118651, Iran., Javadi MA; Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, Iran., Ardestani SK; Department of Immunology, Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417614335, Iran. Electronic address: ardestany@ut.ac.ir., Mahmoudi M; Immunology Research Center, Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9138813944, Iran. Electronic address: mahmoudi@mums.ac.ir., Pourfarzam S; Department of Internal Medicine, Shahed University, Tehran 3319118651, Iran., Mahdavi MRV; Department of Physiology, Shahed University, Tehran 3319118651, Iran. Electronic address: vaezmahdavi@shahed.ac.ir., Yarmohammadi ME; Department of Otolaryngology, Shahid Mostafa Khomeini Hospital, Shahed University, Tehran 3319118651, Iran., Baradaran-Rafii A; Ocular Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, No 23, Paydarfard-9th Boostan St., Pasdaran Ave, Tehran 1666673111, Iran., Jadidi K; Department of Ophthalmology, Baqiyatallah University of Medical Sciences, Tehran 1435915371, Iran., Shariatpanahi S; Department of Internal Medicine, Shahed University, Tehran 3319118651, Iran., Rastin M; Immunology Research Center, Department of Immunology and Allergy, School of Medicine, Mashhad University of Medical Sciences, Mashhad 9138813944, Iran. Electronic address: rastinm@mums.ac.ir., Heidary F; Immunoregulation Research Center, Shahed University, Tehran 3319118651, Iran., Safavi M; Department of Biotechnology, Iranian Research Organization for Science and Technology, Sh. Ehsani Rad St., Enqelab St., Parsa Sq., Ahmadabad Mostoufi Rd., Azadegan Highway, Tehran 3313193685, Iran., Mirsharif ES; Department of Immunology, Shahed University, Tehran 3319118651, Iran., Nasiri Z; Immunoregulation Research Center, Shahed University, Tehran 3319118651, Iran., Ghazanfari T; Immunoregulation Research Center, Shahed University, Tehran 3319118651, Iran; Department of Immunology, Shahed University, Tehran 3319118651, Iran. Electronic address: ghazanfari@shahed.ac.ir.
Jazyk: angličtina
Zdroj: International immunopharmacology [Int Immunopharmacol] 2020 Mar; Vol. 80, pp. 105897. Date of Electronic Publication: 2019 Nov 01.
DOI: 10.1016/j.intimp.2019.105897
Abstrakt: Background: Sulfur mustard (SM) exposure produces extensive systemic and ocular adverse effects on the victims. One of the most important effects is immunological insults that can lead to other organ damages, including the eyes.
Methods: In this descriptive study, 128 SM-exposed veterans with severe eye injury were compared with 31 healthy controls. Tear levels of tumor necrosis factor (TNF)-α and serum concentrations of interleukin (IL)-1α, IL-1β, IL1Ra, IL-6, TNF-α, granulocyte-macrophage colony-stimulating factor (GM-CSF), and Fas Ligand (FasL) were compared between the two groups.
Results: Meibomian gland dysfunction (MGD); tear breakup time (TBUT < 10″); and conjunctival, limbal, and corneal abnormalities were more frequent among the cases (MS-exposed veterans) than the controls. Ocular involvement was mild in 14.8%, moderate in 24.2%, and severe in 60.9% of the cases. Serum levels of IL-1α and FasL were significantly higher among the cases than among the controls (P < 0.001 and P = 0.037, respectively). Also, a significant decrease was observed in serum and tear levels of TNF-α in the cases as compared with controls (P < 0.001, P < 0.001, respectively). Serum levels of FasL were significantly higher in cases with severe ocular involvement than in the controls (P = 0.03). Nonetheless, serum levels of IL-1β, IL-1Ra, IL-1α/IL-1Ra, and IL-6 were not significantly different between the two groups.
Conclusion: Serum levels of IL-1α and FasL may cause different ocular surface abnormalities in SM-exposed patients. Lower tear TNF-α concentration may be due to lower serum levels of this cytokine in these patients.
Competing Interests: Declaration of Competing Interest All authors declared no conflict of interest.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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