Hydrogen peroxide in the ER: A tale of triage.

Autor: Rashdan NA; Molecular and Cellular Physiology, LSU Health Science Center, 1501 Kings Highway, Shreveport, 71130, LA, USA., Pattillo CB; Molecular and Cellular Physiology, LSU Health Science Center, 1501 Kings Highway, Shreveport, 71130, LA, USA. Electronic address: cpatt7@lsuhsc.edu.
Jazyk: angličtina
Zdroj: Redox biology [Redox Biol] 2020 Jan; Vol. 28, pp. 101358. Date of Electronic Publication: 2019 Oct 22.
DOI: 10.1016/j.redox.2019.101358
Abstrakt: Oxidative protein folding in the endoplasmic reticulum (ER) is a significant source of hydrogen peroxide (H 2 O 2 ). For correct protein folding the redox state of the ER must be efficiently regulated. As such, several mechanisms with varying degrees of overlap manage the redox state of the ER. H 2 O 2 also functions as a second messenger playing a role in most aspects of cellular physiology and pathology, requiring tight control of the concentration and flux of H 2 O 2 . Bestetti et al. have demonstrated a role for Aquaporin 11 in transport of H 2 O 2 out of the ER.
(Copyright © 2019. Published by Elsevier B.V.)
Databáze: MEDLINE
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