Advanced nanotherapies to promote neuroregeneration in the injured newborn brain.

Autor: Arteaga Cabeza O; Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA, United States., Mikrogeorgiou A; Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA, United States., Kannan S; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA., Ferriero DM; Department of Pediatrics, University of California San Francisco School of Medicine, San Francisco, CA, United States; Department of Neurology, University of California San Francisco School of Medicine, San Francisco, CA, United States. Electronic address: donna.ferriero@ucsf.edu.
Jazyk: angličtina
Zdroj: Advanced drug delivery reviews [Adv Drug Deliv Rev] 2019 Aug; Vol. 148, pp. 19-37. Date of Electronic Publication: 2019 Oct 31.
DOI: 10.1016/j.addr.2019.10.005
Abstrakt: Neonatal brain injury affects thousands of babies each year and may lead to long-term and permanent physical and neurological problems. Currently, therapeutic hypothermia is standard clinical care for term newborns with moderate to severe neonatal encephalopathy. Nevertheless, it is not completely protective, and additional strategies to restore and promote regeneration are urgently needed. One way to ensure recovery following injury to the immature brain is to augment endogenous regenerative pathways. However, novel strategies such as stem cell therapy, gene therapies and nanotechnology have not been adequately explored in this unique age group. In this perspective review, we describe current efforts that promote neuroprotection and potential targets that are unique to the developing brain, which can be leveraged to facilitate neuroregeneration.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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