| Autor: |
Reyman M; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital of University Medical Centre, Utrecht, the Netherlands.; Spaarne Gasthuis Academy Hoofddorp and Haarlem, Hoofddorp, The Netherlands., van Houten MA; Spaarne Gasthuis Academy Hoofddorp and Haarlem, Hoofddorp, The Netherlands., van Baarle D; National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Bosch AATM; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital of University Medical Centre, Utrecht, the Netherlands., Man WH; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital of University Medical Centre, Utrecht, the Netherlands.; Spaarne Gasthuis Academy Hoofddorp and Haarlem, Hoofddorp, The Netherlands., Chu MLJN; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital of University Medical Centre, Utrecht, the Netherlands., Arp K; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital of University Medical Centre, Utrecht, the Netherlands., Watson RL; Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Sanders EAM; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital of University Medical Centre, Utrecht, the Netherlands.; National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Fuentes S; National Institute for Public Health and the Environment, Bilthoven, The Netherlands., Bogaert D; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital of University Medical Centre, Utrecht, the Netherlands. D.Bogaert@ed.ac.uk.; Medical Research Council/University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. D.Bogaert@ed.ac.uk. |
| Abstrakt: |
The early-life microbiome appears to be affected by mode of delivery, but this effect may depend on intrapartum antibiotic exposure. Here, we assess the effect of delivery mode on gut microbiota, independent of intrapartum antibiotics, by postponing routine antibiotic administration to mothers until after cord clamping in 74 vaginally delivered and 46 caesarean section born infants. The microbiota differs between caesarean section born and vaginally delivered infants over the first year of life, showing enrichment of Bifidobacterium spp., and reduction of Enterococcus and Klebsiella spp. in vaginally delivered infants. The microbiota composition at one week of life is associated with the number of respiratory infections over the first year. The taxa driving this association are more abundant in caesarean section born children, providing a possible link between mode of delivery and susceptibility to infectious outcomes. |
