Letting go of O -glycans.
| Autor: | Saad H; School of Molecular Cell Biology and Biotechnology, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel., Patel C; School of Molecular Cell Biology and Biotechnology, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel., Lederkremer GZ; School of Molecular Cell Biology and Biotechnology, George Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel gerardol@tauex.tau.ac.il. |
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| Jazyk: | angličtina |
| Zdroj: | The Journal of biological chemistry [J Biol Chem] 2019 Nov 01; Vol. 294 (44), pp. 15912-15913. |
| DOI: | 10.1074/jbc.H119.011245 |
| Abstrakt: | The generation of free N -glycans, or unconjugated oligosaccharides derived from N -linked glycoproteins, is well understood, but whether a similar fate awaits O -linked glycoprotein carbohydrates was unknown. Hirayama et al. now reveal, by using only mannose as an energy source, the generation of free O -glycans in Saccharomyces cerevisiae , in the lumen of a secretory compartment, possibly the vacuole. These findings uncover the presence of a possible regulated degradation pathway for O -mannosylated glycoproteins. (© 2019 Saad et al.) |
| Databáze: | MEDLINE |
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