Investigation of the thermodynamic drivers of the interaction between the high mobility group box domain of Sox2 and bacterial lipopolysaccharide.

Autor: Hewitt PH; School of Pharmacy, Department of Pharmaceutical Sciences, Rueckert-Hartman College for Health Professions, Regis University, 3333 Regis Boulevard, H-28, Denver, CO 80221, USA., Pianim ED; School of Pharmacy, Department of Pharmaceutical Sciences, Rueckert-Hartman College for Health Professions, Regis University, 3333 Regis Boulevard, H-28, Denver, CO 80221, USA., DiCesare NA; School of Pharmacy, Department of Pharmaceutical Sciences, Rueckert-Hartman College for Health Professions, Regis University, 3333 Regis Boulevard, H-28, Denver, CO 80221, USA., Gray C; School of Pharmacy, Department of Pharmaceutical Sciences, Rueckert-Hartman College for Health Professions, Regis University, 3333 Regis Boulevard, H-28, Denver, CO 80221, USA., Leong TT; School of Pharmacy, Department of Pharmaceutical Sciences, Rueckert-Hartman College for Health Professions, Regis University, 3333 Regis Boulevard, H-28, Denver, CO 80221, USA., Sakai K; School of Pharmacy, Department of Pharmaceutical Sciences, Rueckert-Hartman College for Health Professions, Regis University, 3333 Regis Boulevard, H-28, Denver, CO 80221, USA., Bernal JV; School of Pharmacy, Department of Pharmaceutical Sciences, Rueckert-Hartman College for Health Professions, Regis University, 3333 Regis Boulevard, H-28, Denver, CO 80221, USA., Shetty SS; School of Pharmacy, Department of Pharmaceutical Sciences, Rueckert-Hartman College for Health Professions, Regis University, 3333 Regis Boulevard, H-28, Denver, CO 80221, USA., Malarkey CS; School of Pharmacy, Department of Pharmaceutical Sciences, Rueckert-Hartman College for Health Professions, Regis University, 3333 Regis Boulevard, H-28, Denver, CO 80221, USA. Electronic address: cmalarkey@regis.edu.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. Biomembranes [Biochim Biophys Acta Biomembr] 2020 Feb 01; Vol. 1862 (2), pp. 183106. Date of Electronic Publication: 2019 Oct 26.
DOI: 10.1016/j.bbamem.2019.183106
Abstrakt: Gastric cancer is associated with high mortality and is preceded by an infection with Helicobacter pylori (H. pylori). H. pylori stimulates inflammation which involves the activation of Toll-like receptor 4 by lipopolysaccharide molecules from the H. pylori. This leads to chronic inflammation that can eventually lead to gastric cancer. Sox2 is a member of the high mobility group (HMG) box family of proteins, and recent studies have shown that HMG box proteins can modulate immune response by altering signaling to Toll-like receptors. Sox2 is overexpressed in most types of cancer with the exception of gastric cancer where expression of Sox2 is decreased. Here, we demonstrate that Sox2 can bind LPS and we investigated the thermodynamic drivers of the Sox2/LPS interaction.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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