| Autor: |
Plazas Guerrero CG; Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán de Rosales, Mexico., Acosta Cota SJ; Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán de Rosales, Mexico., Castro Sánchez FH; Facultad de Ciencias de la Nutrición y Gastronomía, Universidad Autónoma de Sinaloa, Culiacán de Rosales, Mexico., Vergara Jiménez MJ; Facultad de Ciencias de la Nutrición y Gastronomía, Universidad Autónoma de Sinaloa, Culiacán de Rosales, Mexico., Ríos Burgueño ER; Centro de Investigación y Docencia en Ciencias de la Salud, Universidad Autónoma de Sinaloa, Culiacán de Rosales, Mexico., Sarmiento Sánchez JI; Facultad de Ingeniería Civil, Universidad Autónoma de Sinaloa, Culiacán de Rosales, Mexico., Picos Corrales LA; Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán de Rosales, Mexico., Osuna Martínez U; Facultad de Ciencias Químico Biológicas, Universidad Autónoma de Sinaloa, Culiacán de Rosales, Mexico. |
| Abstrakt: |
Overconsumption of sucrose, the main contributor of the total added sugar intake in the world, has been associated with negative metabolic effects related to non-communicable diseases. However, this relationship continues to be a controversial topic and further studies are needed. The aim of this study was to evaluate the sucrose-enriched diet consumption in the development of risk factors associated with type 2 diabetes, atherosclerosis and non-alcoholic fatty liver disease in a murine model. Sucrose-enriched diet-fed rats showed a decrease in food, lipids and protein intake as well as in serum total cholesterol levels, an increase in carbohydrates intake, glucose, insulin, triglycerides, VLDL-c and HDL-c levels and a greater degree of insulin resistance, steatosis and non-alcoholic steatohepatitis. Our results show that sucrose-enriched diet consumption during 25 weeks contribute to the development of risk factors associated with type 2 diabetes, atherosclerosis and non-alcoholic fatty liver disease in male Wistar rats. |
