Hybrid PET- and MR-driven attenuation correction for enhanced 18 F-NaF and 18 F-FDG quantification in cardiovascular PET/MR imaging.

Autor: Karakatsanis NA; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA. nak2032@med.cornell.edu.; Department of Radiology, Weill Cornell Medical College, Cornell University, 515 E 71st Street, S-120, New York, NY, 10021, USA. nak2032@med.cornell.edu., Abgral R; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA.; Department of Nuclear Medicine, University Hospital of Brest, Brest, France., Trivieri MG; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA., Dweck MR; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA.; British Heart Foundation, Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, UK., Robson PM; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA., Calcagno C; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA., Boeykens G; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA.; Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands., Senders ML; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA.; Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands., Mulder WJM; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA.; Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands., Tsoumpas C; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA.; Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK., Fayad ZA; Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, New York, NY, 10029, USA.
Jazyk: angličtina
Zdroj: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology [J Nucl Cardiol] 2020 Aug; Vol. 27 (4), pp. 1126-1141. Date of Electronic Publication: 2019 Oct 30.
DOI: 10.1007/s12350-019-01928-0
Abstrakt: Background: The standard MR Dixon-based attenuation correction (AC) method in positron emission tomography/magnetic resonance (PET/MR) imaging segments only the air, lung, fat and soft-tissues (4-class), thus neglecting the highly attenuating bone tissues and affecting quantification in bones and adjacent vessels. We sought to address this limitation by utilizing the distinctively high bone uptake rate constant K i expected from 18 F-Sodium Fluoride ( 18 F-NaF) to segment bones from PET data and support 5-class hybrid PET/MR-driven AC for 18 F-NaF and 18 F-Fluorodeoxyglucose ( 18 F-FDG) PET/MR cardiovascular imaging.
Methods: We introduce 5-class K i /MR-AC for (i) 18 F-NaF studies where the bones are segmented from Patlak K i images and added as the 5th tissue class to the MR Dixon 4-class AC map. Furthermore, we propose two alternative dual-tracer protocols to permit 5-class K i /MR-AC for (ii) 18 F-FDG-only data, with a streamlined simultaneous administration of 18 F-FDG and 18 F-NaF at 4:1 ratio (R4:1), or (iii) for 18 F-FDG-only or both 18 F-FDG and 18 F-NaF dual-tracer data, by administering 18 F-NaF 90 minutes after an equal 18 F-FDG dosage (R1:1). The K i -driven bone segmentation was validated against computed tomography (CT)-based segmentation in rabbits, followed by PET/MR validation on 108 vertebral bone and carotid wall regions in 16 human volunteers with and without prior indication of carotid atherosclerosis disease (CAD).
Results: In rabbits, we observed similar (< 1.2% mean difference) vertebral bone 18 F-NaF SUV mean scores when applying 5-class AC with K i -segmented bone (5-class K i /CT-AC) vs CT-segmented bone (5-class CT-AC) tissue. Considering the PET data corrected with continuous CT-AC maps as gold-standard, the percentage SUV mean bias was reduced by 17.6% ( 18 F-NaF) and 15.4% (R4:1) with 5-class K i /CT-AC vs 4-class CT-AC. In humans without prior CAD indication, we reported 17.7% and 20% higher 18 F-NaF target-to-background ratio (TBR) at carotid bifurcations wall and vertebral bones, respectively, with 5- vs 4-class AC. In the R4:1 human cohort, the mean 18 F-FDG: 18 F-NaF TBR increased by 12.2% at carotid bifurcations wall and 19.9% at vertebral bones. For the R1:1 cohort of subjects without CAD indication, mean TBR increased by 15.3% ( 18 F-FDG) and 15.5% ( 18 F-NaF) at carotid bifurcations and 21.6% ( 18 F-FDG) and 22.5% ( 18 F-NaF) at vertebral bones. Similar TBR enhancements were observed when applying the proposed AC method to human subjects with prior CAD indication.
Conclusions: K i -driven bone segmentation and 5-class hybrid PET/MR-driven AC is feasible and can significantly enhance 18 F-NaF and 18 F-FDG contrast and quantification in bone tissues and carotid walls.
Databáze: MEDLINE
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