| Autor: |
Tolstun DA; State Institute of Gerontology of National Academy of Medical Sciences of Ukraine, Kiev, Ukraine., Knyazer A; The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, POB 653, 8410501, Beer Sheva, Israel., Tushynska TV; State Institute of Gerontology of National Academy of Medical Sciences of Ukraine, Kiev, Ukraine., Dubiley TA; State Institute of Gerontology of National Academy of Medical Sciences of Ukraine, Kiev, Ukraine., Bezrukov VV; State Institute of Gerontology of National Academy of Medical Sciences of Ukraine, Kiev, Ukraine., Fraifeld VE; State Institute of Gerontology of National Academy of Medical Sciences of Ukraine, Kiev, Ukraine. vadim.fraifeld@gmail.com.; The Shraga Segal Department of Microbiology, Immunology and Genetics, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, POB 653, 8410501, Beer Sheva, Israel. vadim.fraifeld@gmail.com., Muradian KK; State Institute of Gerontology of National Academy of Medical Sciences of Ukraine, Kiev, Ukraine. muradian1944@gmail.com. |
| Abstrakt: |
We hypothesised that hypoxic-hypercapnic environment (HHE) could induce metabolic suppression and associated benefits for health and longevity, as observed in the naked-mole rat (NMR). We developed a model of self-produced HHE (similar to a natural habitat of NMRs), which is simple, reliable and natural, and does not require external sources of gases or complex technical equipment. Here, we showed for the first time that a chronic exposure of mice to HHE could be a unique tool for NMR-like metabolic remodeling, resulting in a long-term and substantial decrease in metabolic rate, body temperature, and food consumption, without significant changes in expression of stress-related genes. Unexpectedly, the HHE accelerated skin wound healing, despite the lower energy expenditure. The self-produced HHE could be considered a model of voluntary calorie restriction. All in all, a chronic exposure to HHE offers a potential of being a lifespan-extending intervention as well as an efficient tool for treating the overweight and associated metabolic disorders. |
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