Gold-coated plant virus as computed tomography imaging contrast agent.

Autor:	Aljabali AAA; Yarmouk University - Faculty of Pharmacy, Department of Pharmaceutical Sciences, Irbid, Jordan., Zoubi MSA; Yarmouk University - Faculty of Medicine, Department of Basic Medical Sciences, Irbid, Jordan., Al-Batanyeh KM; Yarmouk University - Faculty of Science, Department of Biological Sciences, Irbid, Jordan., Al-Radaideh A; Hashemite University - Department of Medical Imaging, Zarqa, Jordan., Obeid MA; Yarmouk University - Faculty of Pharmacy, Department of Pharmaceutical Sciences, Irbid, Jordan., Al Sharabi A; National Agricultural Research Center, Amman, Jordan., Alshaer W; University of Jordan - Cell Therapy Center, Amman, Jordan., AbuFares B; Yarmouk University - Faculty of Science, Department of Biological Sciences, Irbid, Jordan., Al-Zanati T; Yarmouk University - Faculty of Pharmacy, Department of Pharmaceutical Sciences, Irbid, Jordan., Tambuwala MM; SAAD Centre for Pharmacy and Diabetes, School of Pharmacy and Pharmaceutical Science Ulster University, Coleraine, UK., Akbar N; University of Oxford - Cardiovascular Medicine, John Radcliffe Hospital, Oxford, UK., Evans DJ; John Innes Centre, Norwich Research Park, Norwich, UK.
Jazyk:	angličtina
Zdroj:	Beilstein journal of nanotechnology [Beilstein J Nanotechnol] 2019 Oct 07; Vol. 10, pp. 1983-1993. Date of Electronic Publication: 2019 Oct 07 (Print Publication: 2019).
DOI:	10.3762/bjnano.10.195
Abstrakt:	Chemical modification of the surface of viruses, both the interior and the exterior, imparts new functionalities, that have potential applications in nanomedicine. In this study, we developed novel virus-based nanomaterials as a contrast agent for computed tomography (CT) imaging in vitro. The gold-coated cowpea mosaic virus (Au-CPMV) particles were generated by the electrostatic adsorption of positively charged electrolyte on the virus capsid with the subsequent incubation and reduction of anionic gold complexes. Au-CPMV particles as a CT contrast agent offer a fast scan time (less than 2 min), low cost, and biocompatibility and allow for high-resolution imaging with ca. 150 Hounsfield units (HU). The Au-CPMV surface was further modified allowing for the incorporation of targeting molecules of specific cell types. (Copyright © 2019, Aljabali et al.; licensee Beilstein-Institut.)
Databáze:	MEDLINE
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