Comparative Effectiveness of Two Interventions to Increase Colorectal Cancer Screening for Those at Increased Risk Based on Family History: Results of a Randomized Trial.

Autor:	Paskett ED; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio. electra.paskett@osumc.edu.; Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, Columbus, Ohio.; Division of Cancer Prevention and Control, Department of Internal Medicine, College of Medicine, The Ohio State University, Columbus, Ohio.; Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, Ohio., Bernardo BM; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Young GS; Center for Biostatistics, Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio., Katz ML; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.; College of Public Health, The Ohio State University, Columbus, Ohio., Reiter PL; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.; College of Public Health, The Ohio State University, Columbus, Ohio., Tatum CM; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Oliveri JM; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., DeGraffinreid CR; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Gray DM; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.; College of Medicine, Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University, Columbus, Ohio., Pearlman R; Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio., Hampel H; Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, Columbus, Ohio.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2020 Jan; Vol. 29 (1), pp. 3-9. Date of Electronic Publication: 2019 Oct 30.
DOI:	10.1158/1055-9965.EPI-19-0797
Abstrakt:	Background: First-degree relatives (FDR) of patients with colorectal cancer are at risk for colorectal cancer, but may not be up to date with colorectal cancer screening. We sought to determine whether a one-time recommendation about needing colorectal cancer screening using patient navigation (PN) was better than just receiving the recommendation only. Methods: Participants were FDRs of patients with Lynch syndrome-negative colorectal cancer from participating Ohio hospitals. FDRs from 259 families were randomized to a website intervention (528 individuals), which included a survey and personal colorectal cancer screening recommendation, while those from 254 families were randomized to the website plus telephonic PN intervention (515 individuals). Primary outcome was adherence to the personal screening recommendation (to get screened or not to get screened) received from the website. Secondary outcomes examined who benefited from adding PN. Results: At the end of the 14-month follow-up, 78.6% of participants were adherent to their recommendation for colorectal cancer screening with adherence similar between arms ( P = 0.14). Among those who received a recommendation to have a colonoscopy immediately, the website plus PN intervention significantly increased the odds of receiving screening, compared with the website intervention (OR: 2.98; 95% confidence interval, 1.68-5.28). Conclusions: Addition of PN to a website intervention did not improve adherence to a colorectal cancer screening recommendation overall; however, the addition of PN was more effective in increasing adherence among FDRs who needed screening immediately. Impact: These findings provide important information as to when the additional costs of PN are needed to assure colorectal cancer screening among those at high risk for colorectal cancer. (©2019 American Association for Cancer Research.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu