Antimicrobial resistance patterns of Uropathogens isolated from adult women with acute uncomplicated cystitis.

Autor: Al-Zahrani J; Department of Family Medicine, College of Medicine, Prince Sattam bin Abdulaziz University, Al Kharj 11942, Saudi Arabia., Al Dossari K; Department of Family Medicine, College of Medicine, Prince Sattam bin Abdulaziz University, Al Kharj 11942, Saudi Arabia., Gabr AH; Department of Urology, Minia University, Minia, Egypt., Ahmed AF; Department of Urology, Al-Azhar University, Cairo, Egypt., Al Shahrani SA; Department of Urology, College of Medicine, Prince Sattam bin Abdulaziz University, Al Kharj 11942, Saudi Arabia., Al-Ghamdi S; Department of Family Medicine, College of Medicine, Prince Sattam bin Abdulaziz University, Al Kharj 11942, Saudi Arabia. sam3443@gmail.com.
Jazyk: angličtina
Zdroj: BMC microbiology [BMC Microbiol] 2019 Oct 30; Vol. 19 (1), pp. 237. Date of Electronic Publication: 2019 Oct 30.
DOI: 10.1186/s12866-019-1612-6
Abstrakt: Background: To evaluate the antibiotic resistance patterns of uropathogens isolated from adult women with acute community-acquired (CA) uncomplicated cystitis.
Results: Over a one-year period (May 2015-April 2016), the results of susceptibility testing of outpatient midstream urine samples from 5 different laboratories were prospectively evaluated. The study included only adult women with uncomplicated cystitis. The susceptibility testing in all laboratories was performed using the disk diffusion method with the VITEK-2 Compact system. The isolated uropathogens and their resistance to the tested antibiotics were evaluated. Out of 317 adult women with CA uncomplicated cystitis, 179 had a positive culture. The most commonly isolated organism was Escherichia coli (E. coli) (70.4%), followed by Klebsiella (21.2%). The overall resistance rate was highest for ampicillin (85.6%), followed by cefalotin (56.3%), trimethoprim/sulfamethoxazole (54.7%), pipracillin (51.9%), nitrofurantoin (48.8%) and aztreonam (47.4%). Isolated E. coli strains were commonly resistant to ampicillin (80.5%), trimethoprim/sulfamethoxazole (72.2%) and aztreonam (71.4%), followed by cefalotin (55.9%). The overall ciprofloxacin resistance rate was 17.9%, and the resistent was found only with E. coli (25.4%).
Conclusions: Our results may aid in the selection of proper empiric antibiotic therapy for adult women with acute CA uncomplicated cystitis.
Databáze: MEDLINE
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