| Autor: |
Ochoa C; Department of Chemistry, Roy and Diana Vagelos Laboratories , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104 , United States., Solinski AE; Department of Chemistry and the Emory Antibiotic Resistance Center , Emory University , 1515 Dickey Drive , Atlanta , Georgia 30322 , United States., Nowlan M; Department of Chemistry, Roy and Diana Vagelos Laboratories , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104 , United States., Dekarske MM; Department of Chemistry and the Emory Antibiotic Resistance Center , Emory University , 1515 Dickey Drive , Atlanta , Georgia 30322 , United States., Wuest WM; Department of Chemistry and the Emory Antibiotic Resistance Center , Emory University , 1515 Dickey Drive , Atlanta , Georgia 30322 , United States., Kozlowski MC; Department of Chemistry, Roy and Diana Vagelos Laboratories , University of Pennsylvania , 231 South 34th Street , Philadelphia , Pennsylvania 19104 , United States. |
| Abstrakt: |
Targeting Streptococcus mutans is the primary focus in reducing dental caries, one of the most common maladies in the world. Previously, our groups discovered a potent bactericidal biaryl compound that was inspired by the natural product honokiol. Herein, a structure activity relationship (SAR) study to ascertain structural motifs key to inhibition is outlined. Furthermore, mechanism studies show that bacterial membrane disruption is central to the bacterial growth inhibition. During this process, it was discovered that analog C2 demonstrated a 4-fold better therapeutic index compared to the commercially available antimicrobial cetylpyridinium chloride (CPC) making it a viable alternative for oral care. |
