Effect of Concurrent Gonadotropin-Releasing Hormone Agonist Treatment on Dose and Side Effects of Gender-Affirming Hormone Therapy in Adolescent Transgender Patients.

Autor: Jensen RK; Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois., Jensen JK; Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois., Simons LK; Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois., Chen D; Division of Adolescent Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.; Division of Psychiatry, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois., Rosoklija I; Division of Urology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois., Finlayson CA; Division of Endocrinology, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois.
Jazyk: angličtina
Zdroj: Transgender health [Transgend Health] 2019 Oct 29; Vol. 4 (1), pp. 300-303. Date of Electronic Publication: 2019 Oct 29 (Print Publication: 2019).
DOI: 10.1089/trgh.2018.0061
Abstrakt: This retrospective chart review aims to address gaps in the literature regarding the efficacy and interaction of gonadotropin-releasing hormone agonists (GnRHa) and gender-affirming hormone therapies in medical transition regimens in transgender adolescents. We abstracted and reviewed data from 83 patients at our pediatric gender clinic, and found that patients who initiated treatment with GnRHa before gender-affirming hormones (estrogen, testosterone) required lower doses of those hormones than those who did not use GnRHa. The results of this preliminary research provide a foundation for future long-term prospective studies aimed to better understand these relationships.
Competing Interests: Dr. Chen served on an advisory for Endo Pharmaceuticals. This was not related to the formatting or design of this study.
(© Rachel K. Jensen et al. 2019; Published by Mary Ann Liebert, Inc.)
Databáze: MEDLINE
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