Epigenetic dynamics in infancy and the impact of maternal engagement.
| Autor: | Krol KM; Department of Psychology, University of Virginia, Charlottesville, VA, USA.; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Moulder RG; Department of Psychology, University of Virginia, Charlottesville, VA, USA., Lillard TS; Department of Psychology, University of Virginia, Charlottesville, VA, USA., Grossmann T; Department of Psychology, University of Virginia, Charlottesville, VA, USA.; Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany., Connelly JJ; Department of Psychology, University of Virginia, Charlottesville, VA, USA. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Science advances [Sci Adv] 2019 Oct 16; Vol. 5 (10), pp. eaay0680. Date of Electronic Publication: 2019 Oct 16 (Print Publication: 2019). |
| DOI: | 10.1126/sciadv.aay0680 |
| Abstrakt: | The contribution of nature versus nurture to the development of human behavior has been debated for centuries. Here, we offer a piece to this complex puzzle by identifying the human endogenous oxytocin system-known for its critical role in mammalian sociality-as a system sensitive to its early environment and subject to epigenetic change. Recent animal work suggests that early parental care is associated with changes in DNA methylation of conserved regulatory sites within the oxytocin receptor gene ( OXTR m). Through dyadic modeling of behavior and OXTR m status across the first year and a half of life, we translated these findings to 101 human mother-infant dyads. We show that OXTR m is dynamic in infancy and its change is predicted by maternal engagement and reflective of behavioral temperament. We provide evidence for an early window of environmental epigenetic regulation of the oxytocin system, facilitating the emergence of individual differences in human behavior. (Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|