Prevalence of prolonged QT interval in patients with HCV-related chronic liver disease.

Autor:	Gaafar AE; Department of Cardiology, Faculty of Medicine, Helwan University, Mansour st., P.O. 11795 Ain Helwan, Cairo, Egypt. Gaafar911@hotmail.com., Abd El-Aal A; Department of Cardiology, Faculty of Medicine, Helwan University, Mansour st., P.O. 11795 Ain Helwan, Cairo, Egypt., Alboraie M; Department of Internal Medicine, Faculty of Medicine, Al-Azhar University, Cairo, Egypt., Hassan HM; Department of Cardiology, Badr University Hospital, Helwan University, Cairo, Egypt., ElTahan A; New Cairo Viral Hepatitis Treatment Unite, Cairo, Egypt., AbdelRahman Y; Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt., Wifi MN; Department of Internal Medicine, Hepatogastroenterology unite, Cairo University, Cairo, Egypt., Omran D; Department of Endemic Medicine, Faculty of Medicine, Cairo University, Cairo, Egypt., Mansour SA; New Cairo Viral Hepatitis Treatment Unite, Cairo, Egypt., Hassan WM; Faculty of Pharmaceutical Science, Cairo University, Cairo, Egypt., Ismail M; Department of Cardiology, Faculty of Medicine, Helwan University, Mansour st., P.O. 11795 Ain Helwan, Cairo, Egypt., El Kassas M; Department of Endemic Medicine, Faculty of Medicine, Helwan University, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology [Egypt Heart J] 2019 Sep 07; Vol. 71 (1), pp. 15. Date of Electronic Publication: 2019 Sep 07.
DOI:	10.1186/s43044-019-0016-0
Abstrakt:	Background: Hepatitis C virus (HCV) is a common disease in Egypt with a high socioeconomic burden and extra-hepatic manifestations as QT prolongation, but previous studies included mainly patients with advanced liver disease, so in this study, we aimed to delineate the prevalence of QT prolongation in early-stage HCV patients. Results: The study included 874 HCV patients with early cirrhosis; in Child's class A, 57 (6.5%) patients had prolonged QT interval corrected (QTc). There was significant higher proportion of cirrhotic patients in the prolonged QTc group (31.6%) vs. in the normal QTc group (11.5%). QTc was 424.39 ± 36.6 vs. 411.51 ± 32.89 ms in cirrhotic and non-cirrhotic patients, respectively (P, 0.001). There was significant higher proportion of Fibrosis 4 (FIB-4) ≥ 1.45 score in the prolonged QTc (77.2%) vs. in the normal QTc group (56.8%) (P, 0.003). QTc interval was 417.76 ± 34.12 ms in patients with FIB-4 score ≥ 1.45 vs. 406.78 ± 31.95 ms in those with FIB-4 < 1.45 (P, < 0.001). FIB-4 score value of 2.108 predicted prolonged QTc with a sensitivity of 63.2% and a specificity of 64.5% (P, < 0.001). Twenty-four patients of long QTc group sent ECGs after HCV eradication, and 19 patients (79%) showed QTc normalization. Conclusions: HCV is associated with QTc prolongation even in patients with early chronic liver disease stages without significant fibrosis. Also, it is related to the degree of fibrosis and cirrhosis. At a cutoff value of 2.108, FIB-4 score can predict prolonged QTc. HCV eradication is associated with a high incidence of QTc normalization.
Databáze:	MEDLINE
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