The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats.

Autor: Ramos-Romero S; Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, 08034, Spain.; Department of Cell Biology, Physiology & Immunology, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain., Hereu M; Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, 08034, Spain., Atienza L; Department of Pathology, Puerta del Mar University Hospital, Cádiz, 11009, Spain., Amézqueta S; Departament d'Enginyeria Química i Química Analítica and Institut de Biomedicina (IBUB), Universitat de Barcelona, Barcelona, 08028, Spain., Casas J; Research Unit on BioactiveMolecules (RUBAM), Department of Biological Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, 08034, Spain.; Center for Biomedical Research on Hepatic and Digestive Diseases (CIBEREHD), ISCIII, Madrid, 28029, Spain., Muñoz S; Instituto de Investigaciones Marinas (IIM-CSIC), Vigo, 36208, Spain., Medina I; Instituto de Investigaciones Marinas (IIM-CSIC), Vigo, 36208, Spain., Miralles-Pérez B; Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, 43201, Spain., Romeu M; Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, 43201, Spain., Torres JL; Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, 08034, Spain.
Jazyk: angličtina
Zdroj: Molecular nutrition & food research [Mol Nutr Food Res] 2020 Jan; Vol. 64 (1), pp. e1900564. Date of Electronic Publication: 2019 Nov 22.
DOI: 10.1002/mnfr.201900564
Abstrakt: Scope: This study examines the long-term functional effects of d-fagomine on sucrose-induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action.
Methods and Results: Wistar Kyoto rats are fed a 35% sucrose solution with d-fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. The following are recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F 2t isoprostanes (F 2 -IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. d-Fagomine reduces sucrose-induced hypertension, urine uric acid and F 2 -IsoPs (markers of oxidative stress), steatosis, and liver DAGs, without significantly affecting perigonadal fat deposition, and impaired glucose tolerance. It also promotes excretion of enterobacteriales generated by the dietary intervention.
Conclusion: d-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.
(© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)
Databáze: MEDLINE
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