Synthesis of New Cu Complex Based on Natural 5 Z ,9 Z -Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line.

Autor: Dzhemileva LU; Institute of Petrochemistry and Catalysis of RAS (IPC RAS), Prospect Octyabrya, 141, 450075 Ufa, Russian Federation., D'yakonov VA; Institute of Petrochemistry and Catalysis of RAS (IPC RAS), Prospect Octyabrya, 141, 450075 Ufa, Russian Federation., Dil'mukhametova LK; Institute of Petrochemistry and Catalysis of RAS (IPC RAS), Prospect Octyabrya, 141, 450075 Ufa, Russian Federation., Dzhemilev UM; Institute of Petrochemistry and Catalysis of RAS (IPC RAS), Prospect Octyabrya, 141, 450075 Ufa, Russian Federation.
Jazyk: angličtina
Zdroj: ACS omega [ACS Omega] 2019 Oct 11; Vol. 4 (17), pp. 17581-17587. Date of Electronic Publication: 2019 Oct 11 (Print Publication: 2019).
DOI: 10.1021/acsomega.9b02756
Abstrakt: The complex (bipy) 2 Cu(5,9-eicd) was prepared by the reaction of Cu(OAc) 2 with 5 Z ,9 Z -eicosadienoic acid and 2,2'-bipyridine in methanol. The new copper complex showed high antitumor activity in vitro toward A2780cis, A2780, Hek293, K562, HL60, Jurkat, and U937 cell lines and efficiently inhibited human topoisomerase I. Using flow cytofluorometry, (bipy) 2 Cu(5,9-eicd) was studied for the effect on the cell cycle and apoptosis-inducing activity in tumor cells.
Competing Interests: The authors declare no competing financial interest.
(Copyright © 2019 American Chemical Society.)
Databáze: MEDLINE
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