| Autor: |
Zantut PRA; Department of Ophthalmology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Veras MM; Laboratory of Experimental Air Pollution (LIM05), Department of Pathology, Faculdade de Medicina da Universidade São Paulo, São Paulo, Brazil., Yariwake VY; Laboratory of Experimental Air Pollution (LIM05), Department of Pathology, Faculdade de Medicina da Universidade São Paulo, São Paulo, Brazil., Takahashi WY; Department of Ophthalmology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Saldiva PH; Laboratory of Experimental Air Pollution (LIM05), Department of Pathology, Faculdade de Medicina da Universidade São Paulo, São Paulo, Brazil.; Institute for Advanced Studies of the University of São Paulo-IEA, Universidade de São Paulo, São Paulo, Brazil., Young LH; Department of Ophthalmology, Harvard Medical School, Cambridge, MA, USA., Damico FM; Department of Ophthalmology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil., Fajersztajn L; Institute for Advanced Studies of the University of São Paulo-IEA, Universidade de São Paulo, São Paulo, Brazil.; Department Global Brain Health Institute, University of California, San Francisco, CA, USA. |
| Abstrakt: |
Purpose: Cannabis is the most prevalent drug in the world and its consumption is growing. Cannabinoid receptors are present in the human central nervous system. Recent studies show evidence of the effects of cannabinoids on the retina, and synthesising the results of these studies may be relevant for ophthalmologists. Thus, this review adopts standardised, systematic review methodology to investigate the effects of exposure to cannabis and components on the retina. Methods: We searched five online databases for the combined terms for outcome ("retina") and exposure ("cannabis"). Eligibility of studies were conducted by two independent reviewers, and risk of bias was assessed. Results: We retrieved 495 studies, screened 229 studies, assessed 52 studies for eligibility, and included 16 studies for qualitative analysis. The cannabinoids most frequently investigated were delta-9-tetrahydrocannabinol (THC), abnormal cannabidiol, synthetic cannabinoid, and cannabidiol (CDB). The outcomes most studied were neuroretinal dysfunction, followed by vascular effects. The studies also included investigation of neuroprotective and anti-inflammatory effects and teratogenic effects. Conclusions: This review suggests that cannabinoids may have an important role in retinal processing and function. |
