Optical coherence tomography and neurodegeneration in epilepsy.

Autor:	Bayraktar Bilen N; Department of Ophthalmology, Ankara Numune Training and Research Hospital, Ankara, Turkey.; Department of Neurology, Ankara Numune Training and Research Hospital, Ankara, Turkey., Titiz AP; Department of Ophthalmology, Ankara Numune Training and Research Hospital, Ankara, Turkey.; Department of Neurology, Ankara Numune Training and Research Hospital, Ankara, Turkey., Bilen S; Department of Ophthalmology, Ankara Numune Training and Research Hospital, Ankara, Turkey.; Department of Neurology, Ankara Numune Training and Research Hospital, Ankara, Turkey., Polat Gultekin B; Department of Ophthalmology, Ankara Numune Training and Research Hospital, Ankara, Turkey.; Department of Neurology, Ankara Numune Training and Research Hospital, Ankara, Turkey., Sahin Hamurcu M; Department of Ophthalmology, Ankara Numune Training and Research Hospital, Ankara, Turkey.; Department of Neurology, Ankara Numune Training and Research Hospital, Ankara, Turkey., Kalayci D; Department of Ophthalmology, Ankara Numune Training and Research Hospital, Ankara, Turkey.; Department of Neurology, Ankara Numune Training and Research Hospital, Ankara, Turkey.
Jazyk:	angličtina
Zdroj:	European journal of ophthalmology [Eur J Ophthalmol] 2021 Jan; Vol. 31 (1), pp. 252-257. Date of Electronic Publication: 2019 Oct 24.
DOI:	10.1177/1120672119881982
Abstrakt:	Purpose: To compare optical coherence tomography measurements; central macular thickness, ganglion cell complex, and retinal nerve fiber layer thickness in patients with epilepsy versus healthy controls. Methods: We evaluated 28 eyes of 28 patients with epilepsy and 34 eyes of 34 healthy subjects. Central macular thickness, ganglion cell complex, and retinal nerve fiber layer thickness measurements were performed by spectral-domain optical coherence tomography. Results: Superior and superotemporal quadrant ganglion cell complex, average, and superior quadrant retinal nerve fiber layer thickness measurements were significantly lower in epilepsy group compared to healthy control subjects. Central macular thickness was significantly lower in polytherapy group compared to monotherapy group. Ganglion cell complex and retinal nerve fiber layer thickness measurements were not significantly different between polytherapy and monotherapy groups. Conclusion: The present study shows that epileptic patients taking antiepileptic drugs have reduced ganglion cell complex and retinal nerve fiber layer thickness compared to healthy controls. This can be related to the epileptic process in the brain. Optical coherence tomography may be a useful tool for showing the neurodegeneration in patients with epilepsy.
Databáze:	MEDLINE
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