Neurodevelopmental wiring deficits in the Ts65Dn mouse model of Down syndrome.

Autor: Jain S; Department of Biological Sciences, Kent State University, Kent, OH, 44242, USA., Watts CA; School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA., Chung WCJ; Department of Biological Sciences, Kent State University, Kent, OH, 44242, USA; School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA; Brain Health Research Institute, Kent State University, Kent, OH, 44242, USA., Welshhans K; Department of Biological Sciences, Kent State University, Kent, OH, 44242, USA; School of Biomedical Sciences, Kent State University, Kent, OH, 44242, USA; Brain Health Research Institute, Kent State University, Kent, OH, 44242, USA. Electronic address: kwelshha@kent.edu.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2020 Jan 01; Vol. 714, pp. 134569. Date of Electronic Publication: 2019 Oct 20.
DOI: 10.1016/j.neulet.2019.134569
Abstrakt: Down syndrome is the most common genetic cause of intellectual disability and occurs due to the trisomy of human chromosome 21. Adolescent and adult brains from humans with Down syndrome exhibit various neurological phenotypes including a reduction in the size of the corpus callosum, hippocampal commissure and anterior commissure. However, it is unclear when and how these interhemispheric connectivity defects arise. Using the Ts65Dn mouse model of Down syndrome, we examined interhemispheric connectivity in postnatal day 0 (P0) Ts65Dn mouse brains. We find that there is no change in the volume of the corpus callosum or anterior commissure in P0 Ts65Dn mice. However, the volume of the hippocampal commissure is significantly reduced in P0 Ts65Dn mice, and this may contribute to the impaired learning and memory phenotype of this disorder. Interhemispheric connectivity defects that arise during development may be due to disrupted axon growth. In line with this, we find that developing hippocampal neurons display reduced axon length in vitro, as compared to neurons from their euploid littermates. This study is the first to report the presence of defective interhemispheric connectivity at the time of birth in Ts65Dn mice, providing evidence that early therapeutic intervention may be an effective time window for the treatment of Down syndrome.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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