| Autor: |
Michael PM; University of Melbourne Department of Medicine, St. Vincent's Hospital, Australia., Garson OM, Ekert H, Tauro G, Rennie GC, Pilkington GR |
| Jazyk: |
angličtina |
| Zdroj: |
Medical and pediatric oncology [Med Pediatr Oncol] 1988; Vol. 16 (3), pp. 153-61. |
| DOI: |
10.1002/mpo.2950160302 |
| Abstrakt: |
We studied the karyotype in 81 consecutively diagnosed children with acute lymphocytic leukemia (ALL) treated at one institution on a randomized treatment protocol. In 75 patients (93%), a morphological cytogenetic result was obtained, and 57 (65%) were successfully G-banded. Of the 75 patients, 46 (61%) showed abnormal chromosomes, mainly hyperdiploidy and pseudodiploidy, and 29 had no detectable abnormality. Our findings confirmed that the karyotype has prognostic significance. Duration of complete remission was 93% at 42 months for patients with high hyperdiploidy (greater than 50). For patients with an apparently normal karyotype, it was 58%; and for patients with structural abnormalities it was 15%. The significance of these findings was confirmed by multivariate analysis, which showed age and karyotype to be the most important determinants of duration of remission. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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