Testis spectroscopy may predict sperm retrieval rate in men with non-obstructive azoospermia undergoing micro-TESE: A pilot study

Autor: Çelik Ö; Department of Obstetrics and Gynecology, Private Office, Uşak, Turkey, Hatırnaz Ş; In Vitro Fertilization Unit, Medicana International Hospital, Samsun, Turkey, Erşahin A; In Vitro Fertilization Unit, Medicalpark Göztepe Hospital, İstanbul, Turkey, Başbuğ A; Department of Obstetrics and Gynecology, Düzce University Faculty of Medicine, Düzce, Turkey, Yetkin Yıldırım G; Clinic of Obstetrics and Gynecology, University of Health Sciences, Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey, Özener V; Department of Radiology, Barış Radiology Center, İzmir, Turkey, Gürpınar N; Department of Radiology, Barış Radiology Center, İzmir, Turkey, Çelik S; Kent College High School, İzmir, Turkey, Çelik N; Clinic of Biochemistry, University of Health Sciences, Behçet Uz Children’s Training and Research Hospital, İzmir, Turkey, Küçük T; Department of Obstetrics and Gynecology, Acıbadem University Faculty of Medicine, İstanbul, Turkey, Ünlü C; Department of Obstetrics and Gynecology, Acıbadem University Faculty of Medicine, İstanbul, Turkey
Jazyk: angličtina
Zdroj: Journal of the Turkish German Gynecological Association [J Turk Ger Gynecol Assoc] 2020 Jun 08; Vol. 21 (2), pp. 70-78. Date of Electronic Publication: 2019 Oct 23.
DOI: 10.4274/jtgga.galenos.2019.2018.0154
Abstrakt: Objective: To investigate whether prior testis magnetic resonance spectroscopy predicts the success or failure of micro-dissection testicular sperm extraction (micro-TESE) in patients with non-obstructive azoospermia (NOA).
Material and Methods: Nine men with NOA who were scheduled for micro-TESE for the first time, 9 NOA men with a history of previous micro-TESE and 5 fertile men were enrolled. All NOA patients and fertile controls underwent testis spectroscopy. A multi-voxel spectroscopy sequence was used. Testicular signals of choline (Cho), creatine (Cr), myo-inositol (MI), lactate, and lipids were analyzed quantitatively and compared with the results of the micro-TESEs.
Results: The most prominent peaks were Cho and Cr in the fertile controls and NOA subjects with positive sperm retrieval in the micro-TESE. A high Cho peak was detected in 87% of the NOA men with positive sperm retrieval. NOA men without sperm at the previous micro-TESE showed a marked decrease in Cho and Cr signals. For positive sperm retrieval in micro-TESE, the cut-off value of Cho was 1.46 ppm, the cut-off value of Cr was 1.43 ppm, and the cut-off value of MI was 0.79 ppm.
Conclusion: Testis spectroscopy can be used as a non-invasive screening method to predict the success or failure of micro-TESE.
Databáze: MEDLINE
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