Liver transplantation in patients with a history of migration-A German single center comparative analysis.

Autor: Bucher JN; Department of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany., Koenig M; Department of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany., Schoenberg MB; Department of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany., Crispin A; Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University Munich, Munich, Germany., Thomas M; Department of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany., Angele MK; Department of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany., Eser-Valeri D; Department of Psychiatry, Ludwig-Maximilians-University Munich, Munich, Germany., Gerbes AL; Department of Medicine 2, Ludwig-Maximilians-University Munich, Munich, Germany.; Transplantation Centre Munich, Ludwig-Maximilians-University Munich, Munich, Germany.; Liver Centre Munich, Ludwig-Maximilians-University Munich, Munich, Germany., Werner J; Department of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany., Guba MO; Department of General, Visceral and Transplant Surgery, Ludwig-Maximilians-University Munich, Munich, Germany.; Transplantation Centre Munich, Ludwig-Maximilians-University Munich, Munich, Germany.; Liver Centre Munich, Ludwig-Maximilians-University Munich, Munich, Germany.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2019 Oct 22; Vol. 14 (10), pp. e0224116. Date of Electronic Publication: 2019 Oct 22 (Print Publication: 2019).
DOI: 10.1371/journal.pone.0224116
Abstrakt: Liver transplant (LT) programs in Germany increasingly face a multiethnic patient population. To date no outcome data for LT in patients with a history of migration is available for Germany. This complicates decision-making before wait-listing such patients. We conducted a single-center cohort analysis of all primary LT between April 2007 and December 2015, stratified for the history of migration to investigate differences in the outcome. We found transplant rates resembling the proportion of persons with a history of migration in the general public in the region of our center. Differences were found concerning age at LT and prevalence of underlying diseases. Re-Transplant rates, Kaplan-Meier Estimates for overall survival, also after stratification for viral hepatitis, sex, ethnicity or presence of a language-barrier showed no statistical differences. The multivariate analysis showed no migration-related covariate associated with a negative outcome. These results stand in contrast to most of the previous evidence from North America and the UK and need to be taken into consideration during the wait-listing process of patients with a history of migration in need of a LT in centers in the Eurotransplant region.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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